• Abstract

    Urinary tract infection is a frequent condition in companion animals, where several pathogens may be involved, among them, multidrug-resistant agents to antimicrobials, making their treatment difficult. In this context, adjuvant therapies can be indicated to assist in the treatment. Thus, the objective of this study was to report the antimicrobial action of a solution containing procaine hydrochloride associated with sodium bicarbonate, intravesically administered, in a male feline (domestic cat) with urinary tract infection due to multidrug-resistant microorganism. The cat with a history of urinary infection developed after urethrostomy was attended. The animal was receiving treatment with the antimicrobial amoxicillin with clavulanate, however, without positive clinical and laboratory response. After performing urine culture and antibiogram, where the microorganism Proteus mirabilis resistant to 18 classes of tested antimicrobials was isolated, an intravesical application of 2.0 mL of 0.7% procaine solution plus sodium bicarbonate was performed. After seven days of this application, a new urine culture and antibiogram were performed, which did not show any growth of microorganisms. It is concluded that the 0.7% procaine hydrochloride solution associated with intravesical sodium bicarbonate showed antimicrobial action against multi-resistant Proteus mirabilis, which causes urinary infection in a cat.

  • References

    1. Bahr Arias MV, Assis Battaglia L, Aiello G (2008) Identificação da susceptibilidade antimicrobiana de bactérias isoladas de cães e gatos com feridas traumáticas contaminadas e infectadas. Semina: Ciências Agrárias. Universidade Estadual de Londrina 29:861-874.
    2. Carvalho VM, Spinola T, Tavolari F, Irino K, Oliveira RM, Ramos MCC (2014) Infecções do trato urinário (ITU) de cães e gatos: etiologia e resistência aos antimicrobianos. Pesquisa Veterinária Brasileira 34:62-70. DOI: 10.1590/S0100-736X2014000100011
    3. Castro RA (2011) Bases para la terapia neural em caninos y felinos. Buenos Aires: Dunken. 304p.
    4. Cruz Y, Fayad RF (2011) Microtúbulos y terapia neural: propuesta de una investigación promisoria. Revista Med de la Facultad de Medicina 19:82-92.
    5. Dokai O, Laub K, Stercz B (2018) Bicarbonate Inhibits Bacterial Growth and Bioflim Formation of Prevalent Cystic Fibrosis Pathogens. Fronties in Microbiology 9:1-12. DOI: 10.3389/fmicb.2018.02245
    6. Ferreira MC, Nobre D, Oliveira MGX, Oliveira MCV, Cunha MPV, Menão MC, Dellova DCA, Knobl T (2014) Agentes bacterianos isolados de cães e gatos com infecção urinária: perfil de sensibilidade aos antimicrobianos. Atas de saúde ambiental - Asa 2:29-37.
    7. Fongaro J (2011) Identificação microbiana de urocultura. Trabalho apresentado à disciplina de Trabalho de Conclusão de Curso, como exigência para obtenção de título de licenciado em Ciências Biológicas. Faculdade Assis Gurgacz. Cascavel.
    8. Gonçalves BAL (2020) Avaliação in vitro da ação antimicrobiana do cloridrato de procaína associado ou não ao bicarbonato de sódio sobre patógenos causadores de infecção urinária. Dissertação apresentada ao Programa de Pós-Graduação em Ciência Animal da Universidade Federal de Minas Gerais, como requisito parcial à obtenção do título de Mestre. UFMG. Belo Horizonte.
    9. Gonçalves BA, Vianna LR, Andrade CC, Oliveira JSG (2020) Treatment of Feline Idiopathic Cystitis (Pandora´s Syndrome) with Neural Therapy - Case Report. Ecronicon EC Veterinary Science 15:01-05.
    10. Labedan B (1988) Increase in Permeability of Escherichia coli Outer Membrane by Local Anesthetics and Penetration of Antibiotics. Antimicrobial Agents and Chemotherapy 32:153-155.
    11. Ollin SJ, Bartges JW (2015) Urinary Tract Infections, Treatment/Comparative Therapeutics. Veterinary Clinics: Small Animal 45:721-746.
    12. Reuter URM, Oettmeier R, Nazlikul H (2017) Procaine and Procaine-Base-Infusion: A Review of the Safety and Fields of Application after Twenty Years of Use. Sciforschen Clinical Research 4:1-7.
    13. Shrestha LB, Baral R, Khanal B (2019) Comparative study of antimicrobial resistance and biofilm formation among Gram-positive uropathogens isolated from community-acquired urinary tract infections and catheter-associated urinary tract infections. Infection and Drug Resistance 12:957-963.
    14. Vianna LR, Gonçalves BAL (2020) pH e condutividade do cloridrato de procaína em diferentes concentrações utilizadas na terapia neural. Multidisciplinary Science Journal 3:e2021002:1-5. DOI: 10.29327/multiscience.2021002

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How to cite

Gonçalves, B. A. L., Vianna, L. R., Carvalho, A. de M., & Freitas, P. M. C. (2022). Neural Therapy in a multidrug-resistant urinary tract infection in a cat: case report. Multidisciplinary Science Journal, 4(4), 2022017. https://doi.org/10.31893/multiscience.2022017
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