• Abstract

    The Information on the 2019 coronavirus illness (COVID-19) in Egypt's severe cerebrovascular consequences is scant. In cases of acute cerebrovascular disease (CVD), this study aimed to examine the radiological and clinical characteristics of patients with and without COVID-19. Prospective research evaluated CVD patients with and without COVID-19 who were hospitalized at Qena University Hospital (QUH) before the global epidemic. Patients diagnosed with COVID-19 and able to be treated at either assist or Aswan University Hospitals (AAUH) for cardiovascular disease were compared. The data included patient demographics, medical history, risk factors, clinical presentation, comorbidities, and imaging results from CT and MRI scans of the chest and brain. In overall 439 individuals with COVID-19, 55 (12.5%) experienced acute CVD. Of these, 13 patients (2.9%) experienced hemorrhagic CVD, whereas 42 (9.6%) suffered an ischemic stroke. 180 of the 250 non-COVID-19 individuals suffered from ischemic stroke, and 70 from hemorrhagic stroke. Many COVID-19 patients had large vascular occlusions (LVO), which is a significant portion of individuals who had ischemic stroke symptoms (40 vs. 7.2%, P <0.001) and was considerably more reciprocal than in CVD patients who were not COVID-19. Comorbidities were noted in 44 instances (80% of the total). Sufferers of ischemic stroke who had COVID-19 were much more likely to have dangerous elements such as hypertension and Ischemic Heart Disease (IHD) as well as concomitant conditions like hepatitis and kidney disease. Additionally, 6.5% of individuals with LVO had a hemorrhagic transition, and 23.5% had hemorrhagic CVD. In our research, individuals with COVID-19 often had severe CVD. The most typical LVO was. The most frequent risk factors, such as hypertension, IHD, and anemia, may make the clinical presentation worse. Patients with CVD often had comorbid conditions, but many also had high liver enzymes and creatinine levels that were partly brought on by the COVID-19 disease itself. The new findings start to describe the range of CVD linked to COVID-19 in patients from Upper Egypt.

     

  • References

    1. Burkert J, Patil S (2020) Acute cerebrovascular event in a COVID-19 positive patient immediately after commencing non-invasive ventilation. BMJ Case Reports CP, 13(9), p.e237737.DOI: 10.1136/bcr-2020-237737
    2. Cantone M, Lanza G, Puglisi V, Vinciguerra L, Mandelli J, Fisicaro F, Pennisi M, Bella R, Ciurleo R, Bramanti A (2021) Hypertensive crisis in acute cerebrovascular diseases presenting at the emergency department: a narrative review. Brain Sciences 11:70. DOI: 10.3390/brainsci11010070
    3. Dakovic I, Göttler J, Mpotsaris A (2022) Acute cerebrovascular events-fundamentals. Radiologie (Heidelberg, Germany). DOI:10.1007/s00117-022-01084-6
    4. Dhamoon MS, Thaler A, Gururangan K, Kohli A, Sisniega D, Wheelwright D, Mensching C, Fifi JT, Fara MG, Jette N, Cohen E (2021) Acute cerebrovascular events with COVID-19 infection. Stroke 52:48-56. DOI: 10.1161/STROKEAHA.120.031668
    5. Hawkes MA, Anderson CS, Rabinstein AA (2022) Blood pressure variability after cerebrovascular events: a possible new therapeutic target: a narrative review. Neurology 99:150-160. DOI: 10.1212/WNL.0000000000200856
    6. Larson AS, Savastano L, Kadirvel R, Kallmes DF, Hassan AE, Brinjikji W (2020) Coronavirus disease 2019 and the cerebrovascular‐cardiovascular systems: what Do We Know So Far?. Journal of the American Heart Association 9:e016793. DOI:10.1161/JAHA.120.016793
    7. Maida CD, Daidone M, Pacinella G, Norrito RL, Pinto A, Tuttolomondo A (2022) Diabetes and ischemic stroke: An old and new relationship an overview of the close interaction between these diseases. International Journal of Molecular Sciences 23:2397. DOI: 10.3390/ijms23042397
    8. Mo J, Huang L, Peng J, Ocak U, Zhang J, Zhang JH (2019) Autonomic disturbances in acute cerebrovascular disease. Neuroscience Bulletin 35:133-144. DOI: 10.1155/2022/3363672
    9. Ramamoorthy V, Chan K, Appunni S, Zhang Z, Ahmed MA, McGranaghan P, Saxena A, Rubens M (2023) Prevalence and trends of perioperative major adverse cardiovascular and cerebrovascular events during cancer surgeries. Scientific Reports, 13(1), p.2410. DOI: 10.1038/s41598-023-29632-7
    10. Rothstein A, Oldridge O, Schwennesen H, Do D, Cucchiara BL (2020) Acute cerebrovascular events in hospitalized COVID-19 patients. Stroke 51:e219-e222. DOI: 10.1161/STROKEAHA.120.030995
    11. Schwarz V, Mahfoud F, Lauder L, Reith W, Behnke S, Smola S, Rissland J, Pfuhl T, Scheller B, Böhm M, Ewen S (2020) Decline of emergency admissions for cardiovascular and cerebrovascular events after the outbreak of COVID-19. Clinical Research in Cardiology 109:1500-1506. DOI: 10.1007/s00392-020-01688-9
    12. Sojka M, Drelich-Zbroja A, Kuczyńska M, Cheda M, Dąbrowska I, Kopyto E, Halczuk I, Zbroja M, Cyranka W, Jargiełło T (2022) Ischemic and Hemorrhagic Cerebrovascular Events Related to COVID-19 Coagulopathy and Hypoxemia. International Journal of Environmental Research and Public Health, 19:11823. DOI: 10.3390/ijerph191811823
    13. Takagi K, Naganuma T, Tada N, Yamanaka F, Araki M, Shira S, Higashimori A, Watanabe Y, Yamamoto M, Hayashida K (2020) The predictors of peri-procedural and sub-acute cerebrovascular events following TAVR from OCEAN-TAVI registry. Cardiovascular Revascularization Medicine 21:732-738. DOI: 10.1016/j.carrev.2019.10.013
    14. Testa A, Biondi-Zoccai G, Anticoli S, Pezzella FR, Mangiardi M, Marchegiani G, Frati G, Sciarretta S, Perrotta A, Peruzzi M, Cavarretta E (2022) Cluster analysis of weather and pollution features and its role in predicting acute cardiac or cerebrovascular events. Minerva Medica. DOI: 10.23736/s0026-4806.22.08036-3
    15. Toyoda K, Yoshimura S, Nakai M, Koga M, Sasahara Y, Sonoda K, Kamiyama K, Yazawa Y, Kawada S, Sasaki M, Terasaki T (2022) Twenty-year change in severity and outcome of ischemic and hemorrhagic strokes. JAMA neurology 79:61-69. DOI: 10.1001/jamaneurol.2021.4346
    16. Wadowski PP, Schörgenhofer C, Rieder T, Ertl S, Pultar J, Serles W, Sycha T, Mayer F, Koppensteiner R, Gremmel T, Jilma B (2022) Microvascular rarefaction in patients with cerebrovascular events. Microvascular Research 140:104300. DOI:10.1016/j.mvr.2021.104300

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Raghav, S., Jyothi R., R., & Mukhopadhyay, S. (2023). Clinical and radiological characteristics of Covid-19 patients with acute cerebrovascular vents: A meta-analysis. Multidisciplinary Science Journal, 5, 2023ss0526. https://doi.org/10.31893/multiscience.2023ss0526
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