• Abstract

    Neural Therapy is a treatment of Russian and German origins that consists of the use of local anesthetics in low concentrations, such as procaine. Procaine is a synthetic anesthetic discovered in 1905. Its use was further developed in Germany at the beginning of the 20th century by the Huneke brothers. Studies show that in addition to the anesthetic, anti-inflammatory, and antimicrobial functions, procaine also has an anti-tumor action. Currently, there is a greater tutor - animal approach, which has led to the inclusion of dogs and cats in the family environment. In this way, the animals' longevity has increased and, consequently, the incidence of neoplasms in companion animals has also increased in recent years. A situation that brings several underlying problems, such as paraneoplastic syndromes and stress shared with the family. Currently, cancer is a major cause of death in dogs and cats. Studies show that procaine can produce DNA demethylation and reexpression of tumor suppressor genes and therefore can be a therapeutic option for cancer patients. Veterinary oncology has been standing out with new approaches. Today there is greater efficiency of treatments, whether isolated or associated with other practices. The objective of this work is to show that Neural Therapy can be a treatment option for cancer patients.

  • References

    1. Adler DMT, Damborg P, Verwilghen DR (2017) The antimicrobial activity of bupivacaine, lidocaine and mepivacaine against equine pathogens: An investigation of 40 bacterial isolates. The Veterinary Journal 223:27-31.
    2. Bulcão, RP, Arbo, MD, Roehrs, M, Paniz, C, Cervi, FL, Thiesen, FV, Leal, MB, Garcia, SC (2011) Procaína: Efeitos farmacológicos e toxicológicos. Revista de Ciências Farmacêuticas Básica e Aplicada 32:297-303.
    3. Burrel, SE (2008) Salud, enfermaria y terapia neural. 193p.
    4. Bravo-Monsalvo, A, Vázquez-Chagoyán, J, Gutiérrez, L, Sumano, H (2008) Clinical efficacy of neural therapy for the treatment of atopic dermatitis in dogs. Acta Veterinaria Hungarica 56:459-469.
    5. Cassuto, J, Sinclair, R, Bonderovic, M (2006) Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiologica Scandinavica 50:265–282.
    6. Castro, RA (2011) Bases para la terapia neural em caninos y felinos. Buenos Aires: Dunken. 304p.
    7. Cruz, Y, Naffah, RF (2011) Microtúbulos y terapia neural: propuesta de una investigación promisoria. Revista Med de la Facultad de Medicina19:82-92.
    8. De La Roche, J.C.P (1981) La Medicina Biologica: Una Medicina no Comprometida. Colombia. 110p.
    9. Ding, ZN, Yoshita, Y, Hirota, K, Yamamoto, K, Kobayashi, T, Murakami, S (1992) Brainstem auditory evoked potentials during procaine toxicity in dogs. Canadian Journal of Anaesthesia 39:600–603.
    10. Fischer, L (2000) Terapia Neural, según Huneke. Fundamentos, técnica, aplicación práctica. México: Hippokrates Verlag Stuttgart. 272p.
    11. Franco, N, Degregori, EB, Mattos, NF, Teixeira, LG, Rosa, MP, Contesini, EA (2019) Utilização de antibióticos quimioterápicos na oncológica de pequenos animais: Revisão. PUBVET 13:1-8.
    12. Gonçalves, BAL, Vianna, LR, Fernandes, AL, Teixeira, ACB, Amaral, KP (2019a) Tratamento com Terapia Neural em cão com sequela de cinomose: Relato de caso. PUBVET 13:1-6.
    13. Gonçalves, BA, Vianna, LR, Andrade, CC (2019b) Alopecia psicogênica em gato tratada com Terapia Neural: Relato de caso. PUBVET 13:1-6.
    14. Gonçalves, BA, Vianna, LR, Andrade, CC, Oliveira, JSG (2020) Treatment of Feline Idiopathic Cystitis (Pandora´s Syndrome) with Neural Therapy – Case Report. Ecronicon EC Veterinary Science 15:01-05.
    15. Harris, GR (2010) Effective Treatment of Chronic Pain by the Integration of Neural Therapy and Prolotherapy. Journal of Prolotherapy 2:377-386.
    16. Illera, JCJ, Cárdenas, ML (2011) Procaína, epigenética y terapia neural en el cáncer,¿ una alternativa terapéutica?. Revista de Los Estudiantes de Medicina de La Universidade Industrial de Santander. Médicas UIS 24:165-171.
    17. Klinghardt, DK (1993) Neural therapy. Journal of Neurological and Orthopaedic Medicine and Surgery14:109-114.
    18. Koval, PR (2014) Medicina para o ser singular com dor persistente ou outros problemas complexos. Buenos Aires: Ediciones incertidumbre, 212p.
    19. Li, C, Gao, S, Li, X, Li, C, Ma, L (2018 a) Procaine inhibits the proliferation and migration of colon cancer cells through inactivation of the ERK/MAPK/FAK pathways by regulation of rhoA. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 26:209-217.
    20. Li, YC, Wang, Y, Li, DD, Zhang, Y, Zhao, TC, Li, CF (2018 b) Procaine is a specific DNA methylation inhibitor with anti‐tumor effect for human gastric cancer. Journal of cellular biochemistry 119:2440-2449.
    21. Ma, XW, Li, Y, Han, XC, Xin, QZ (2016) The effect of low dosage of procaine on lung cancer cell proliferation. European Review for Medical Pharmacological Sciences 20:4791-4795.
    22. Moreira, L, Kinappe, L, Duhart, D, Motta, AS (2018) A geriatria canina e o manejo das doenças neoplásicas: Revisão. PUBVET 12:1-7.
    23. Reuter, URM, Oettmeier, R, Nazlikul, H (2017) Procaine and Procaine-Base-Infusion: A Review of the Safety and Fields of Aplication after Twenty Years of Use. Sciforschen Clinical Research 44:1-7.
    24. Sabit, H, Samy, MB, Said, OAM, El-Zawahri MM (2016) Procaine induces epigenetic changes in HCT116 colon cancer cells. Genetics research international 2016:1-7.
    25. Vianna, LR, Gonçalves, BAL (2016) Nasce uma nova especialidade na Medicina Veterinaria Brasileira: Terapia Neural e Odontologia NeuroFocal. Revista V&Z Minas 130:16-21.
    26. Vianna, LR, Gonçalves, BAL (2017) Entenda a terapia neural. Revista CFMV 74:44-47.
    27. Vieira, DS, Moura, JB, Silva, FES, Taniwaki, F, Cardoso, TC (2018) Atividade antitumoral da folha da Hymenaea martiana hayne em células mamárias de cães. PUBVET 12:1-6.
    28. Villar-Garea, A, Fraga, MF, Espada, J, Esteller, M (2003) Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer research 63:4984-4989.
    29. Ying, B, Huang, H, Li, H, Song, M, Wu, S, Ying, H (2017) Procaine inhibits proliferation and migration and promotes cell apoptosis in osteosarcoma cells by upregulation of microRNA-133b. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 25:1463-1470.
    30. Weinschenk, S (2012) Neural therapy - a review of the therapeutic use of local anesthetics. Acupuncture and related therapies 1:5-9.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2020 Multidisciplinary Reviews

How to cite

Gonçalves, B. A. L., Vianna, L. R., & Andrade, C. de C. (2020). Neural Therapy: a treatment option in oncological patients. Multidisciplinary Reviews, 3, 2020014. https://doi.org/10.29327/multi.2020014
  • Article viewed - 1563
  • PDF (PORTUGUESE) downloaded - 574