• Abstract

    The following article includes a chart illustrating the dietary components of various food classes that are involved in the pathogenesis of colorectal cancer (CRC), as well as information on the key players in the digestive tract microbiota and the many dysfunctions involved in the onset or progression of CRC. With its complex course throughout history, colorectal cancer has advanced the understanding of its initiation and improvement. Dating back to old remedial compositions, acknowledgments of side impacts related to colorectal cancer propose an early certification of the ailment, in apparent hate toward the truth that illustrative confinements hampered comprehension. It was not until the 19th century that restorative headways were locked in pathologists to observe the characteristic highlights of colorectal tumors underneath the opening up central point. As the 20th century spread, analysts recognized chance components such as family history, caloric count, and way of life, whereas expressive techniques such as colonoscopy progressed, engaging in prior disclosure and treatment. The understanding of how colorectal cancer starts and improves through eating less has advanced over time. By and enormous, the utilization of ruddy and organized meats has been related to an expanded chance of start. These meats contain compounds such as nitrates and nitrites that can serve as diagram carcinogens inside the colon. Understanding how diets affect epigenetic modifications inside the intestinal mucosa is particularly important since abnormally methylated genes may serve as early detection and prognostic markers for colon cancer. Epigenetic changes, such as changes in methylation, are potentially reversible and, therefore, offer interesting targets for supportive and preventative therapy, unlike intrinsic changes in cancer. The history of colorectal cancer highlights the urgent need for dependable progress, prompt intervention, and individualized treatment in the fight against this serious illness. Epigenetics is at the center of contemporary pharmacological research because it addresses complex forms that turn on and off the manifestation of particular traits and explains the methods and links between genes and the environment during different stages of life. However, the majority of vertical nuclear instruments related to metabolic, epigenetic, and epigenomic diseases are still unknown and need further research. The growing role of microbial metabolites and a few clearly beneficial dietary additions in the management of CRC are outlined in this article.

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Pillai, P. R., Mendhe, D., & Liju, A. M. (2024). Diet and epigenetics of colon carcinogenesis: A review article. Multidisciplinary Reviews, (| Accepted Articles). Retrieved from https://malque.pub/ojs/index.php/mr/article/view/2986
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