Review of recent research on hair fall: Insights and perspectives

Kanishka Pal Verma; Meghali Kaple

Keywords:

Recent Advancements

Hairfall

Abstract

This review aims to consolidate recent advancements in understanding the various contributors to hair loss, shedding light on this intricate phenomenon's established and emerging facets. Despite the considerable impact on individuals, the complex nature of hair loss poses challenges in diagnosis and treatment, necessitating a nuanced exploration of contributing factors. By synthesizing findings from genetic studies, hormonal analyses, nutritional assessments, and investigations into environmental influences, I aim to provide an up-to-date and cohesive understanding of the intricate web of factors contributing to hair loss.
References
1. Khare S. Efficacy of Dr. SKS Hair Booster Serum in the Treatment of Female Pattern Alopecia in Patients With PCOS: An Open-Label, Non-randomized, Prospective Study. Cureus. 2023 Sep;15(9):e44941.
2. Mysore V, Parthasaradhi A, Kharkar RD, Ghoshal AK, Ganjoo A, Ravichandran G, et al. Expert consensus on the management of Telogen Effluvium in India. Int J Trichology. 2019;11(3):107–12.
3. Tunuguntla MN, Mathew B, Quadri A, Movva S, Raghavan P, Rajpal S, et al. Inherited Hairlessness: A Case Study of Familial Congenital Atrichia. Cureus. 2023 Apr;15(4):e37608.
4. Wadstein J, Thom E, Gadzhigoroeva A. Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium. Dermatol Res Pract. 2020;2020:8125081.
5. Shi X, Tuan H, Na X, Yang H, Yang Y, Zhang Y, et al. The Association between Sugar-Sweetened Beverages and Male Pattern Hair Loss in Young Men. Nutrients. 2023 Jan 1;15(1):214.
6. Patel BC, Malhotra R. Cilia Incarnata. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 Feb 17]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK536979/
7. Yan X, Tayier M, Cheang ST, Liao Z, Dong Y, Yang Y, et al. Hair repigmentation and regrowth in a dupilumab-treated paediatric patient with alopecia areata and atopic dermatitis: a case report. Ther Adv Chronic Dis. 2023;14:20406223231191049.
8. King B, Zhang X, Harcha WG, Szepietowski JC, Shapiro J, Lynde C, et al. A plain language summary on ritlecitinib treatment for adults and adolescents with alopecia areata. Immunotherapy. 2023 Oct;15(14):1093–103.
9. Elgoyhen AB. The α9α10 acetylcholine receptor: A non-neuronal nicotinic receptor. Pharmacol Res. 2023 Apr;190:106735.
10. Sedik RNM. The clinical course and outcomes of SARS-CoV-2 virus infection in children: a 24-week follow-up study in Sulaimaniyah, Iraq. BMC Pediatr. 2023 Jun 17;23(1):303.
11. Mahadi AR, Rafi MA, Shahriar T, Seemanta S, Rabbani MG, Akter M, et al. Association Between Hair Diseases and COVID-19 Pandemic-Related Stress: A Cross-Sectional Study Analysis. Front Med (Lausanne). 2022;9:876561.
12. Hussain Shah SS, Aalia B, Raza A, Najeeb S, Rehman AU. Management Of Childhood Steroid Dependent Nephrotic Syndrome With Cyclophosphamide - An Experience At Ayub Teaching Hospital, Abbottabad. J Ayub Med Coll Abbottabad. 2021;33(2):213–6.
13. Stenholm S, Suorsa K, Leskinen T, Myllyntausta S, Pulakka A, Pentti J, et al. Finnish Retirement and Aging Study: a prospective cohort study. BMJ Open. 2023 Dec 10;13(12):e076976.
14. Chan HM, Fediuk K, Batal M, Sadik T, Tikhonov C, Ing A, et al. The First Nations Food, Nutrition and Environment Study (2008-2018)-rationale, design, methods and lessons learned. Can J Public Health. 2021 Jun;112(Suppl 1):8–19.
15. Luo Y, Zhang C, Ma L, Zhang Y, Liu Z, Chen L, et al. Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome. J Lipid Res. 2022 Jun;63(6):100228.
16. Sun M, Deng Y, Cao X, Xiao L, Ding Q, Luo F, et al. Effects of Natural Polyphenols on Skin and Hair Health: A Review. Molecules. 2022 Nov 14;27(22):7832.
17. Gokce N, Basgoz N, Kenanoglu S, Akalin H, Ozkul Y, Ergoren MC, et al. An overview of the genetic aspects of hair loss and its connection with nutrition. J Prev Med Hyg. 2022 Jun;63(2 Suppl 3):E228–38.
18. Katta R, Huang S. Skin, Hair and Nail Supplements: An Evidence-Based Approach. Skin Therapy Lett. 2019 Sep;24(5):7–13.
19. Hwang SB, Park HJ, Lee BH. Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/β-Catenin and BMP Signaling Pathways. Int J Mol Sci. 2022 Oct 7;23(19):11904.
20. Palmer KNB, Okechukwu A, Mantina NM, Melton FL, Kram NAZ, Hatcher J, et al. Hair Stylists as Lay Health Workers: Perspectives of Black Women on Salon-Based Health Promotion. Inquiry. 2022;59:469580221093183.
21. Chen CL, Huang WY, Wang EHC, Tai KY, Lin SJ. Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration. J Biomed Sci. 2020 Mar 14;27(1):43.
22. Marceau K, Wang W, Robertson O, Shirtcliff EA. A systematic review of hair cortisol during pregnancy: Reference ranges and methodological considerations. Psychoneuroendocrinology. 2020 Dec;122:104904.
23. Staufenbiel SM, Penninx BWJH, Spijker AT, Elzinga BM, van Rossum EFC. Hair cortisol, stress exposure, and mental health in humans: a systematic review. Psychoneuroendocrinology. 2013 Aug;38(8):1220–35.
24. Chang CJ, O’Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, et al. Use of Straighteners and Other Hair Products and Incident Uterine Cancer. J Natl Cancer Inst. 2022 Dec 8;114(12):1636–45.
25. Iob E, Steptoe A. Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic Stress. Curr Cardiol Rep. 2019 Aug 30;21(10):116.
26. Alopecia Areata: An Updated Review for 2023 - PubMed [Internet]. [cited 2024 Mar 1]. Available from: https://pubmed.ncbi.nlm.nih.gov/37340563/
27. Pulickal JK, Kaliyadan F. Traction Alopecia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 Mar 1]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK470434/
28. Anagen Effluvium - PubMed [Internet]. [cited 2024 Mar 1]. Available from: https://pubmed.ncbi.nlm.nih.gov/29493918/
29. Shwartz Y, Gonzalez-Celeiro M, Chen CL, Pasolli HA, Sheu SH, Fan SMY, et al. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells. Cell. 2020 Aug 6;182(3):578-593.e19.
30. Peterson A, Nair LS. Hair Follicle Stem Cells for Tissue Regeneration. Tissue Eng Part B Rev. 2022 Aug;28(4):695–706.
31. Sustained Loss of Bdnf Affects Peripheral but Not Central Vestibular Targets - PubMed [Internet]. [cited 2024 Mar 1]. Available from: https://pubmed.ncbi.nlm.nih.gov/34975728/
32. Madnani N, Khan K. Hair cosmetics. Indian J Dermatol Venereol Leprol. 2013;79(5):654–67.

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How to cite

Verma, K. P., & Kaple, M. (2024). Review of recent research on hair fall: Insights and perspectives. Multidisciplinary Reviews, (| Accepted Articles). Retrieved from https://malque.pub/ojs/index.php/mr/article/view/2873

[1] Khare S. Efficacy of Dr. SKS Hair Booster Serum in the Treatment of Female Pattern Alopecia in Patients With PCOS: An Open-Label, Non-randomized, Prospective Study. Cureus. 2023 Sep;15(9):e44941.

[2] Mysore V, Parthasaradhi A, Kharkar RD, Ghoshal AK, Ganjoo A, Ravichandran G, et al. Expert consensus on the management of Telogen Effluvium in India. Int J Trichology. 2019;11(3):107–12.

[3] Tunuguntla MN, Mathew B, Quadri A, Movva S, Raghavan P, Rajpal S, et al. Inherited Hairlessness: A Case Study of Familial Congenital Atrichia. Cureus. 2023 Apr;15(4):e37608.

[4] Wadstein J, Thom E, Gadzhigoroeva A. Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium. Dermatol Res Pract. 2020;2020:8125081.

[5] Shi X, Tuan H, Na X, Yang H, Yang Y, Zhang Y, et al. The Association between Sugar-Sweetened Beverages and Male Pattern Hair Loss in Young Men. Nutrients. 2023 Jan 1;15(1):214.

[6] Patel BC, Malhotra R. Cilia Incarnata. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 Feb 17]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK536979/

[7] Yan X, Tayier M, Cheang ST, Liao Z, Dong Y, Yang Y, et al. Hair repigmentation and regrowth in a dupilumab-treated paediatric patient with alopecia areata and atopic dermatitis: a case report. Ther Adv Chronic Dis. 2023;14:20406223231191049.

[8] King B, Zhang X, Harcha WG, Szepietowski JC, Shapiro J, Lynde C, et al. A plain language summary on ritlecitinib treatment for adults and adolescents with alopecia areata. Immunotherapy. 2023 Oct;15(14):1093–103.

[9] Elgoyhen AB. The α9α10 acetylcholine receptor: A non-neuronal nicotinic receptor. Pharmacol Res. 2023 Apr;190:106735.

[10] Sedik RNM. The clinical course and outcomes of SARS-CoV-2 virus infection in children: a 24-week follow-up study in Sulaimaniyah, Iraq. BMC Pediatr. 2023 Jun 17;23(1):303.

[11] Mahadi AR, Rafi MA, Shahriar T, Seemanta S, Rabbani MG, Akter M, et al. Association Between Hair Diseases and COVID-19 Pandemic-Related Stress: A Cross-Sectional Study Analysis. Front Med (Lausanne). 2022;9:876561.

[12] Hussain Shah SS, Aalia B, Raza A, Najeeb S, Rehman AU. Management Of Childhood Steroid Dependent Nephrotic Syndrome With Cyclophosphamide - An Experience At Ayub Teaching Hospital, Abbottabad. J Ayub Med Coll Abbottabad. 2021;33(2):213–6.

[13] Stenholm S, Suorsa K, Leskinen T, Myllyntausta S, Pulakka A, Pentti J, et al. Finnish Retirement and Aging Study: a prospective cohort study. BMJ Open. 2023 Dec 10;13(12):e076976.

[14] Chan HM, Fediuk K, Batal M, Sadik T, Tikhonov C, Ing A, et al. The First Nations Food, Nutrition and Environment Study (2008-2018)-rationale, design, methods and lessons learned. Can J Public Health. 2021 Jun;112(Suppl 1):8–19.

[15] Luo Y, Zhang C, Ma L, Zhang Y, Liu Z, Chen L, et al. Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome. J Lipid Res. 2022 Jun;63(6):100228.

[16] Sun M, Deng Y, Cao X, Xiao L, Ding Q, Luo F, et al. Effects of Natural Polyphenols on Skin and Hair Health: A Review. Molecules. 2022 Nov 14;27(22):7832.

[17] Gokce N, Basgoz N, Kenanoglu S, Akalin H, Ozkul Y, Ergoren MC, et al. An overview of the genetic aspects of hair loss and its connection with nutrition. J Prev Med Hyg. 2022 Jun;63(2 Suppl 3):E228–38.

[18] Katta R, Huang S. Skin, Hair and Nail Supplements: An Evidence-Based Approach. Skin Therapy Lett. 2019 Sep;24(5):7–13.

[19] Hwang SB, Park HJ, Lee BH. Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/β-Catenin and BMP Signaling Pathways. Int J Mol Sci. 2022 Oct 7;23(19):11904.

[20] Palmer KNB, Okechukwu A, Mantina NM, Melton FL, Kram NAZ, Hatcher J, et al. Hair Stylists as Lay Health Workers: Perspectives of Black Women on Salon-Based Health Promotion. Inquiry. 2022;59:469580221093183.

[21] Chen CL, Huang WY, Wang EHC, Tai KY, Lin SJ. Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration. J Biomed Sci. 2020 Mar 14;27(1):43.

[22] Marceau K, Wang W, Robertson O, Shirtcliff EA. A systematic review of hair cortisol during pregnancy: Reference ranges and methodological considerations. Psychoneuroendocrinology. 2020 Dec;122:104904.

[23] Staufenbiel SM, Penninx BWJH, Spijker AT, Elzinga BM, van Rossum EFC. Hair cortisol, stress exposure, and mental health in humans: a systematic review. Psychoneuroendocrinology. 2013 Aug;38(8):1220–35.

[24] Chang CJ, O’Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, et al. Use of Straighteners and Other Hair Products and Incident Uterine Cancer. J Natl Cancer Inst. 2022 Dec 8;114(12):1636–45.

[25] Iob E, Steptoe A. Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic Stress. Curr Cardiol Rep. 2019 Aug 30;21(10):116.

[26] Alopecia Areata: An Updated Review for 2023 - PubMed [Internet]. [cited 2024 Mar 1]. Available from: https://pubmed.ncbi.nlm.nih.gov/37340563/

[27] Pulickal JK, Kaliyadan F. Traction Alopecia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 Mar 1]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK470434/

[28] Anagen Effluvium - PubMed [Internet]. [cited 2024 Mar 1]. Available from: https://pubmed.ncbi.nlm.nih.gov/29493918/

[29] Shwartz Y, Gonzalez-Celeiro M, Chen CL, Pasolli HA, Sheu SH, Fan SMY, et al. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells. Cell. 2020 Aug 6;182(3):578-593.e19.

[30] Peterson A, Nair LS. Hair Follicle Stem Cells for Tissue Regeneration. Tissue Eng Part B Rev. 2022 Aug;28(4):695–706.

[31] Sustained Loss of Bdnf Affects Peripheral but Not Central Vestibular Targets - PubMed [Internet]. [cited 2024 Mar 1]. Available from: https://pubmed.ncbi.nlm.nih.gov/34975728/

[32] Madnani N, Khan K. Hair cosmetics. Indian J Dermatol Venereol Leprol. 2013;79(5):654–67.

Abstract

References

How to cite