A mini-review on bovine stromal mesenchymal cells sustainability and innovativeness

Authors

  • Jamila Cristina Baptistella University of São Paulo State, College of Veterinary Medicine, Dep. Production and Animal Health, Laboratory Cell Culture and Anatomy Section, Araçatuba, São Paulo State, Brazil
  • Letícia Colin Panegossi University of São Paulo State, College of Veterinary Medicine, Dep. Production and Animal Health, Anatomy and Embryology section. Araçatuba, São Paulo State, Brazil https://orcid.org/0000-0002-4416-3413
  • Rafaela Vilar Constantini University of São Paulo State, College of Veterinary Medicine, Dep. Production and Animal Health, Anatomy and Embryology section. Araçatuba, São Paulo State, Brazil
  • Tereza Cristina Cardoso University of São Paulo State, College of Veterinary Medicine, Dep. Production and Animal Health, Laboratory Cell Culture and Anatomy Section, Araçatuba, São Paulo State, Brazil
  • Roberto Gameiro de Carvalho University of São Paulo State, College of Veterinary Medicine, Dep. Production and Animal Health, Laboratory Cell Culture and Anatomy Section, Araçatuba, SP, Brazil

DOI:

https://doi.org/10.31893/multirev.2022007

Keywords:

cattle, connective tissue, stem cells, umbilical cord

Abstract

Animal experiments are conducted to demonstrate proof-of-concept and mechanisms of action, provide safe cell culture methods, carry out tissue engineering, and study infectious disease pathogenesis. Regarding the sustainable principles of the 3Rs, namely, refinement, reduction, and replacement, animal and human biological systems have been used. By definition, the Wharton's jelly (WJ) layer is a connective tissue localized in the middle of the umbilical vessels and amniotic epithelium. In this review, we would like to state that these cells belong to the division of primitive stromal cells. Because the WJ layer is an economical source of cells, the use of this resource would improve areas such as regenerative medicine, biotechnology, and agronomics worldwide in accordance with sustainability.

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Overview of bovine umbilical cord obtained after parturition. The illustration on the top left shows a Bos taurus cow with a female calf. A) Representation of the bovine umbilical cord morphology. The lower left image shows a schematic of the components of the bovine umbilical cord: (1) umbilical vein; (2) umbilical cord blood; (3) Wharton's jelly region; and 4) bWJ-MSCs.

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CITATION

PUBLISHED: 2022-03-18

How to Cite

Baptistella, J. C., Colin Panegossi, L., Vilar Constantini, R., Cardoso, T. C., & Gameiro de Carvalho, R. (2022). A mini-review on bovine stromal mesenchymal cells sustainability and innovativeness. Multidisciplinary Reviews, 5(2), e2022007. https://doi.org/10.31893/multirev.2022007

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Mini-Review