A influência da vitamina d na depressão pós-parto

Julia de Paula Pereira da Silva; Everton dos Santos Barros; Ricardo Souhail Haddad

doi:10.31893/multirev.2022006

Keywords:

Abstract

Postpartum depression is considered a childbirth-related mood disorder and starts between the first day and four months after delivery. Its clinical manifestation includes extreme sadness, pleasure loss, sleep disturbances, guilt feelings and worthlessness, anxiety, and suicidal thoughts. Maternal depression can impair the baby's behavioral, emotional, and cognitive development. Vitamin D is considered a steroid hormone derived from cholesterol, with endogenous synthesis after sun exposure, and can be found through food sources such as fish and egg yolks. Low serum 25-Hydroxy-vitamin D (25(OH)D) are linked to several diseases: osteopenia; mood disorder; cardiovascular diseases; premenstrual syndrome; major depressive disorder; cancer; autoimmune disorders; pre-eclampsia; seasonal affective disorder; and postpartum depression. Studies have shown that low levels of 25-OH-D can be related to symptoms of postpartum depression, whose symptoms of depression are obtained through validated questionnaires. This review paper aimed to establish the relationship between low vitamin D levels and postpartum depression symptoms. A search for review articles published between 2016 and 2021 was performed. The articles analyzed show that low vitamin D levels are related to postpartum depression symptoms. More research is needed to track vitamin D levels during pregnancy to prevent and/or reduce postpartum depression.
References
1. Aghajafari F, Letourneau N, Mahinpey N, Cosic N, Giesbrecht G (2018) Vitamin D deficiency and antenatal and postpartum depression: a systematic review. Nutrients 10:478. DOI: 10.3390/nu10040478
2. Amini S, Jafarirad S, Amani R (2019) Postpartum depression and vitamin D: A systematic review. Critical reviews in food science and nutrition 59:1514-1520. DOI: 10.1080/10408398.2017.1423276
3. Amodeo G, Laurenzi PF, Santucci A, Cuomo A, Bolognesi S, Goracci A, Rossi R, Crescenzi BB, Neal SM, Fagiolini A (2020) Advances in treatment for postpartum major depressive disorder. Expert Opinion on Pharmacotherapy 21:1685-1698. DOI: 10.1080/14656566.2020.1779702
4. Anderson G, Maes M (2013) Postpartum depression: psychoneuroimmunological underpinnings and treatment. Neuropsychiatric Disease and Treatment 9:277. DOI: 10.2147/NDT.S25320
5. American Psychiatric Association (2014) DSM-5: Manual diagnóstico e estatístico de transtornos mentais. Artmed, Porto Alegre.
6. Brummelte S, Galea LA (2010) Depression during pregnancy and postpartum: contribution of stress and ovarian hormones. Progress in Neuro-Psychopharmacology and Biological Psychiatry 34:766-776. DOI: 10.1016/j.pnpbp.2009.09.006
7. Brummelte S, Galea LA (2016) Postpartum depression: Etiology, treatment and consequences for maternal care. Hormones and behavior 77:153-166. DOI: 10.1016/j.yhbeh.2015.08.008
8. Castro LCG (2011) O sistema endocrinológico vitamina D. Arquivos Brasileiros de Endocrinologia e Metabologia 55:566-575. DOI: 10.1590/S0004-27302011000800010
9. Cozzolino SM, Cominetti C (2013) Bases bioquímicas e fisiológicas da nutrição: nas diferentes fases da vida, na saúde e na doença. Manole, Barueri.
10. Ellsworth-Bowers ER, Corwin EJ (2012) Nutrition and the psychoneuroimmunology of postpartum depression. Nutrition research reviews 25:180-192. DOI: 10.1017/S0954422412000091
11. Fernando C (2019) A Review of the Association Between Vitamin D and Postpartum Depression. Other Undergraduate Research. 5. Disponível em: https://scholarworks.gvsu.edu/cgi/viewcontent.cgi?article=1004&context=bms_undergrad Acesso em: 12 de outubro de 2021.
12. Filha MMT, Ayers S, Da Gama SGN, Do Carmo Leal M (2016) Factors associated with postpartum depressive symptomatology in Brazil: the Birth in Brazil National Research Study, 2011/2012. Journal of affective disorders, 194:159-167. DOI: 10.1016/j.jad.2016.01.020
13. Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T (2005) Perinatal depression: a systematic review of prevalence and incidence. Obstetrics & Gynecology:1071-1083. DOI: 10.1097/01.AOG.0000183597.31630.db
14. Halbreich U, Karkun S (2006) Cross-cultural and social diversity of prevalence of postpartum depression and depressive symptoms. Journal of affective disorders 91:97-111. DOI: 10.1016/j.jad.2005.12.051
15. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Weaver CM (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of clinical endocrinology & metabolism 96:1911-1930. DOI: 10.1210/jc.2011-0385
16. Humble MB (2010) Vitamin D, light and mental health. Journal of Photochemistry and Photobiology B: Biology, 101:142-149. DOI: 10.1016/j.jphotobiol.2010.08.003
17. Jacka FN, Maes M, Pasco JA, Williams LJ, Berk M (2012) Nutrient intakes and the common mental disorders in women. Journal of affective disorders 141:79-85. DOI: 10.1016/j.jad.2012.02.018
18. Juruena MF, Cleare AJ, Pariante CM (2004) O eixo hipotálamo-pituitária-adrenal, a função dos receptores de glicocorticóides e sua importância na depressão. Brazilian Journal of Psychiatry 26:189-201. DOI: 10.1590/S1516-44462004000300009.
19. Krishnan V, Nestler EJ (2010) Linking molecules to mood: new insight into the biology of depression. American Journal of Psychiatry 167:1305-1320. DOI: 10.1176/appi.ajp.2009.10030434
20. Leung BM, Kaplan BJ, Field CJ, Tough S, Eliasziw M, Gomez MF, Gagnon L (2013) Prenatal micronutrient supplementation and postpartum depressive symptoms in a pregnancy cohort. BMC pregnancy and childbirth 13:1-11. DOI: 10.1186/1471-2393-13-2
21. Leung BM, Kaplan BJ (2009) Perinatal depression: prevalence, risks, and the nutrition link—a review of the literature. Journal of the American Dietetic Association 109:1566-1575. DOI: 10.1016/j.jada.2009.06.368
22. Lin YH, Chen CM, Su HM, Mu SC, Chang ML, Chu PY, Li SC (2019) Association between postpartum nutritional status and postpartum depression symptoms. Nutrients 11:1204. DOI: 10.3390/nu11061204
23. Maia JAV, Guerra CN, Maia DDAC (2019) Suplementação de vitamina d na puericultura: Revisão de literatura. Cadernos ESP-Revista Científica da Escola de Saúde Pública do Ceará 13:75-82.
24. Marques CDL, Dantas AT, Fragoso TS, Duarte ALBP (2010) A importância dos níveis de vitamina D nas doenças autoimunes. Revista Brasileira de Reumatologia 50:67-80. DOI: 10.1590/S0482-50042010000100007
25. Mccann JC, Ames BN (2008) Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? The FASEB Journal 22:982-1001. DOI: 10.1096/fj.07-9326rev
26. Murphy PK, Wagner CL (2008) Vitamin D and mood disorders among women: an integrative review. Journal of Midwifery & Women's Health 53:440-446. DOI: 10.1016/j.jmwh.2008.04.014
27. Nobre RR (2017) Nutrição aplicada ao tratamento da depressão. 25f. Trabalho de Conclusão de Curso (Graduação em Nutrição) - Universidade Anhanguera, São Paulo.
28. Payne JL, Maguire J (2019) Pathophysiological mechanisms implicated in postpartum depression. Frontiers in neuroendocrinology 52:165-180. DOI: 10.1016/j.yfrne.2018.12.001
29. Porto CM, Da Silva TDPS, Sougey EB (2019) Contribuições da vitamina D no tratamento de sintomas depressivos e fatores de risco cardiovascular: protocolo de estudo para um ensaio clínico randomizado, duplo-cego e controlado por placebo. Trials 20. DOI: 10.1186/s13063-019-3699-3
30. Robinson CJ, Alanis MC, Wagner CL, Hollis BW, Johnson DD (2010) Plasma 25-hydroxyvitamin D levels in early-onset severe pre-eclampsia. American journal of obstetrics and gynecology 203:366-e1. DOI: 10.1016/j.ajog.2010.06.036
31. Rosa JS, Junior JRS, Real AG, Siqueira LQ, Rosa CS (2017) Influência dos ácidos graxos ômega 3 e vitamina D na depressão: uma breve revisão. Revista de Ciências Médicas e Biológicas 16:217-223. DOI: 10.9771/cmbio.v16i2.17896
32. Sanacora G, Treccani G, Popoli M (2012) Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology 62:63-77. DOI: 10.1016/j.neuropharm.2011.07.036
33. Santos HLBS, Silva SDS, Paula ED, Pereira-Ferrari L, Mikami L, Riedi CA, Rosário NA (2018) Mutações do gene do receptor de vitamina de níveis séricos de vitamina d em crianças com asma. Revista Paulista de Pediatria 36:269-274. DOI: 10.1590/1984-0462/;2018;36;3;00016
34. Slomian J, Honvo G, Emonts P, Reginster JY, Bruyère O (2019) Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes. Women's Health 15:1745506519844044. DOI: 10.1177/1745506519844044
35. Sparling TM, Henschke N, Nesbitt RC, Gabrysch S (2017) The role of diet and nutritional supplementation in perinatal depression: a systematic review. Maternal & child nutrition 13:1. DOI: 10.1111/mcn.12235
36. Suri R, Stowe ZN, Cohen LS, Newport DJ, Burt VK, Aquino-Elias AR, Knight BT, Mintz J, Altshuler LL (2017) Prospective longitudinal study of predictors of postpartum-onset depression in women with a history of major depressive disorder. The Journal of clinical psychiatry 78:15118. DOI: 10.4088/JCP.15m10427.
37. Thompson SM, Kallarackal AJ, Kvarta MD, Van Dyke AM, Legates TA, Cai X (2015) An excitatory synapse hypothesis of depression. Trends in Neurosciences 38:279-294. DOI: 10.1016/j.tins.2015.03.003
38. Tiderencel KA, Zelig R, Parker A (2019) The Relationship Between Vitamin D and Postpartum Depression: A Review of Current Literature. Topics in Clinical Nutrition 34:301-314. DOI: 10.1097/TIN.0000000000000187
39. Vaziri F, Nasiri S, Tavana Z, Dabbaghmanesh MH, Sharif F, Jafari P (2016) A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers. BMC Pregnancy and Childbirth 16. DOI: 10.1186/s12884-016-1024-7
40. Wang J, Liu N, Sun W, Chen D, Zhao J, Zhang W (2018) Association between vitamin D deficiency and antepartum and postpartum depression: a systematic review and meta-analysis of longitudinal studies. Archives of gynecology and obstetrics 298:1045-1059. DOI: 10.1007/s00404-018-4902-6

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to cite

da Silva, J. de P. P., Barros, E. dos S., & Haddad, R. S. (2022). The influence of vitamin D on postpartum depression. Multidisciplinary Reviews, 5(2), 2022006. https://doi.org/10.31893/multirev.2022006

[1] Aghajafari F, Letourneau N, Mahinpey N, Cosic N, Giesbrecht G (2018) Vitamin D deficiency and antenatal and postpartum depression: a systematic review. Nutrients 10:478. DOI: 10.3390/nu10040478

[2] Amini S, Jafarirad S, Amani R (2019) Postpartum depression and vitamin D: A systematic review. Critical reviews in food science and nutrition 59:1514-1520. DOI: 10.1080/10408398.2017.1423276

[3] Amodeo G, Laurenzi PF, Santucci A, Cuomo A, Bolognesi S, Goracci A, Rossi R, Crescenzi BB, Neal SM, Fagiolini A (2020) Advances in treatment for postpartum major depressive disorder. Expert Opinion on Pharmacotherapy 21:1685-1698. DOI: 10.1080/14656566.2020.1779702

[4] Anderson G, Maes M (2013) Postpartum depression: psychoneuroimmunological underpinnings and treatment. Neuropsychiatric Disease and Treatment 9:277. DOI: 10.2147/NDT.S25320

[5] American Psychiatric Association (2014) DSM-5: Manual diagnóstico e estatístico de transtornos mentais. Artmed, Porto Alegre.

[6] Brummelte S, Galea LA (2010) Depression during pregnancy and postpartum: contribution of stress and ovarian hormones. Progress in Neuro-Psychopharmacology and Biological Psychiatry 34:766-776. DOI: 10.1016/j.pnpbp.2009.09.006

[7] Brummelte S, Galea LA (2016) Postpartum depression: Etiology, treatment and consequences for maternal care. Hormones and behavior 77:153-166. DOI: 10.1016/j.yhbeh.2015.08.008

[8] Castro LCG (2011) O sistema endocrinológico vitamina D. Arquivos Brasileiros de Endocrinologia e Metabologia 55:566-575. DOI: 10.1590/S0004-27302011000800010

[9] Cozzolino SM, Cominetti C (2013) Bases bioquímicas e fisiológicas da nutrição: nas diferentes fases da vida, na saúde e na doença. Manole, Barueri.

[10] Ellsworth-Bowers ER, Corwin EJ (2012) Nutrition and the psychoneuroimmunology of postpartum depression. Nutrition research reviews 25:180-192. DOI: 10.1017/S0954422412000091

[11] Fernando C (2019) A Review of the Association Between Vitamin D and Postpartum Depression. Other Undergraduate Research. 5. Disponível em: https://scholarworks.gvsu.edu/cgi/viewcontent.cgi?article=1004&context=bms_undergrad Acesso em: 12 de outubro de 2021.

[12] Filha MMT, Ayers S, Da Gama SGN, Do Carmo Leal M (2016) Factors associated with postpartum depressive symptomatology in Brazil: the Birth in Brazil National Research Study, 2011/2012. Journal of affective disorders, 194:159-167. DOI: 10.1016/j.jad.2016.01.020

[13] Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T (2005) Perinatal depression: a systematic review of prevalence and incidence. Obstetrics & Gynecology:1071-1083. DOI: 10.1097/01.AOG.0000183597.31630.db

[14] Halbreich U, Karkun S (2006) Cross-cultural and social diversity of prevalence of postpartum depression and depressive symptoms. Journal of affective disorders 91:97-111. DOI: 10.1016/j.jad.2005.12.051

[15] Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Weaver CM (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. The Journal of clinical endocrinology & metabolism 96:1911-1930. DOI: 10.1210/jc.2011-0385

[16] Humble MB (2010) Vitamin D, light and mental health. Journal of Photochemistry and Photobiology B: Biology, 101:142-149. DOI: 10.1016/j.jphotobiol.2010.08.003

[17] Jacka FN, Maes M, Pasco JA, Williams LJ, Berk M (2012) Nutrient intakes and the common mental disorders in women. Journal of affective disorders 141:79-85. DOI: 10.1016/j.jad.2012.02.018

[18] Juruena MF, Cleare AJ, Pariante CM (2004) O eixo hipotálamo-pituitária-adrenal, a função dos receptores de glicocorticóides e sua importância na depressão. Brazilian Journal of Psychiatry 26:189-201. DOI: 10.1590/S1516-44462004000300009.

[19] Krishnan V, Nestler EJ (2010) Linking molecules to mood: new insight into the biology of depression. American Journal of Psychiatry 167:1305-1320. DOI: 10.1176/appi.ajp.2009.10030434

[20] Leung BM, Kaplan BJ, Field CJ, Tough S, Eliasziw M, Gomez MF, Gagnon L (2013) Prenatal micronutrient supplementation and postpartum depressive symptoms in a pregnancy cohort. BMC pregnancy and childbirth 13:1-11. DOI: 10.1186/1471-2393-13-2

[21] Leung BM, Kaplan BJ (2009) Perinatal depression: prevalence, risks, and the nutrition link—a review of the literature. Journal of the American Dietetic Association 109:1566-1575. DOI: 10.1016/j.jada.2009.06.368

[22] Lin YH, Chen CM, Su HM, Mu SC, Chang ML, Chu PY, Li SC (2019) Association between postpartum nutritional status and postpartum depression symptoms. Nutrients 11:1204. DOI: 10.3390/nu11061204

[23] Maia JAV, Guerra CN, Maia DDAC (2019) Suplementação de vitamina d na puericultura: Revisão de literatura. Cadernos ESP-Revista Científica da Escola de Saúde Pública do Ceará 13:75-82.

[24] Marques CDL, Dantas AT, Fragoso TS, Duarte ALBP (2010) A importância dos níveis de vitamina D nas doenças autoimunes. Revista Brasileira de Reumatologia 50:67-80. DOI: 10.1590/S0482-50042010000100007

[25] Mccann JC, Ames BN (2008) Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? The FASEB Journal 22:982-1001. DOI: 10.1096/fj.07-9326rev

[26] Murphy PK, Wagner CL (2008) Vitamin D and mood disorders among women: an integrative review. Journal of Midwifery & Women's Health 53:440-446. DOI: 10.1016/j.jmwh.2008.04.014

[27] Nobre RR (2017) Nutrição aplicada ao tratamento da depressão. 25f. Trabalho de Conclusão de Curso (Graduação em Nutrição) - Universidade Anhanguera, São Paulo.

[28] Payne JL, Maguire J (2019) Pathophysiological mechanisms implicated in postpartum depression. Frontiers in neuroendocrinology 52:165-180. DOI: 10.1016/j.yfrne.2018.12.001

[29] Porto CM, Da Silva TDPS, Sougey EB (2019) Contribuições da vitamina D no tratamento de sintomas depressivos e fatores de risco cardiovascular: protocolo de estudo para um ensaio clínico randomizado, duplo-cego e controlado por placebo. Trials 20. DOI: 10.1186/s13063-019-3699-3

[30] Robinson CJ, Alanis MC, Wagner CL, Hollis BW, Johnson DD (2010) Plasma 25-hydroxyvitamin D levels in early-onset severe pre-eclampsia. American journal of obstetrics and gynecology 203:366-e1. DOI: 10.1016/j.ajog.2010.06.036

[31] Rosa JS, Junior JRS, Real AG, Siqueira LQ, Rosa CS (2017) Influência dos ácidos graxos ômega 3 e vitamina D na depressão: uma breve revisão. Revista de Ciências Médicas e Biológicas 16:217-223. DOI: 10.9771/cmbio.v16i2.17896

[32] Sanacora G, Treccani G, Popoli M (2012) Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology 62:63-77. DOI: 10.1016/j.neuropharm.2011.07.036

[33] Santos HLBS, Silva SDS, Paula ED, Pereira-Ferrari L, Mikami L, Riedi CA, Rosário NA (2018) Mutações do gene do receptor de vitamina de níveis séricos de vitamina d em crianças com asma. Revista Paulista de Pediatria 36:269-274. DOI: 10.1590/1984-0462/;2018;36;3;00016

[34] Slomian J, Honvo G, Emonts P, Reginster JY, Bruyère O (2019) Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes. Women's Health 15:1745506519844044. DOI: 10.1177/1745506519844044

[35] Sparling TM, Henschke N, Nesbitt RC, Gabrysch S (2017) The role of diet and nutritional supplementation in perinatal depression: a systematic review. Maternal & child nutrition 13:1. DOI: 10.1111/mcn.12235

[36] Suri R, Stowe ZN, Cohen LS, Newport DJ, Burt VK, Aquino-Elias AR, Knight BT, Mintz J, Altshuler LL (2017) Prospective longitudinal study of predictors of postpartum-onset depression in women with a history of major depressive disorder. The Journal of clinical psychiatry 78:15118. DOI: 10.4088/JCP.15m10427.

[37] Thompson SM, Kallarackal AJ, Kvarta MD, Van Dyke AM, Legates TA, Cai X (2015) An excitatory synapse hypothesis of depression. Trends in Neurosciences 38:279-294. DOI: 10.1016/j.tins.2015.03.003

[38] Tiderencel KA, Zelig R, Parker A (2019) The Relationship Between Vitamin D and Postpartum Depression: A Review of Current Literature. Topics in Clinical Nutrition 34:301-314. DOI: 10.1097/TIN.0000000000000187

[39] Vaziri F, Nasiri S, Tavana Z, Dabbaghmanesh MH, Sharif F, Jafari P (2016) A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers. BMC Pregnancy and Childbirth 16. DOI: 10.1186/s12884-016-1024-7

[40] Wang J, Liu N, Sun W, Chen D, Zhao J, Zhang W (2018) Association between vitamin D deficiency and antepartum and postpartum depression: a systematic review and meta-analysis of longitudinal studies. Archives of gynecology and obstetrics 298:1045-1059. DOI: 10.1007/s00404-018-4902-6

Abstract

References

How to cite