Diabetes mellitus patients with increased death rates and clinical complications in patients with CoV-19 pneumonia: A systematic review

Kavina Ganapathy; Saubhagya Mishra; Ekta Kapoor; Devanshu J. Patel

doi:10.31893/multirev.2023ss007

Keywords:

COVID-19

Intensive Care Units (ICUs)

Diabetes Mellitus

Pneumonia

Abstract

Diabetes Mellitus (DM) is a chronic condition that has been associated with Corona virus (CV) sickness and has the potential to cause catastrophic multisystemic consequences. They used a complete meta-analysis and review to examine the connection among DM and a bad prognosis in COVID-19 pneumonia individuals. We searched many online databases for articles assessing the correlation between DM and outcome in COVID-19 pneumonia. This study's principal result was an undesirable interaction of three secondary results: the occurrence of severe cardiovascular disease (CVD), acute respiratory distress syndrome (ARDS), and death. All 17 studies had 6452 participants. After eliminating the duplicates, the number of records remained at 350. After first looking at the titles and abstracts, we discarded 310 articles. After reviewing 43 full-text publications, 13 were ruled ineligible owing to a lack of mortality, interest, or disease progression outcomes, including those for severe ARDS which is disease progression, ARDS, Mortality and COVID-19 severity, were increased in COVID-19 patients with DM.
References
1. Ahmadikia K, Hashemi SJ, Khodavaisy S, Getso MI, Alijani N, Badali H, Mirhendi H, Salehi M, Tabari A, MohammadiArdehali M & Kord M (2021). The double‐edged sword of systemic corticosteroid therapy in viral pneumonia A case report and comparative review of influenza‐associated mucormycosis versus COVID‐19 associated mucormycosis. Mycoses, 64(8), 798-808. DOI: 10.1111/myc.13256.
2. Ahmed N, Mahmood MS, Ullah MA, Araf Y, Rahaman TI, Moin AT & Hosen MJ (2022). COVID-19-associated candidiasis: possible patho-mechanism, predisposing factors, and prevention strategies. Current Microbiology, 79(5), 127. DOI: 10.1007/s00284-022-02824-6.
3. Al-kuraishy HM, Al-Maiahy TJ, Al-Gareeb AI, Musa RA & Ali ZH (2020). CV pneumonia in an Iraqi pregnant woman with preterm delivery. Asian Pacific Journal of Reproduction, 9(3), 156-8. DOI: 10.4103/2305-0500.282984
4. Baqi S, Naz A, Sayeed MA, Khan S, Ismail H, Kumar V, Somjimal H, Aneela J, Imtiaz S, Aftab S & Kumar V (2021). Clinical characteristics and outcome of patients with severe CVpneumonia at a public sector hospital in Karachi, Pakistan. Cureus, 13(2). DOI: 10.7759/cureus.13107.
5. Barnes JA, Eid MA, Creager MA & Goodney PP (2020). Epidemiology and risk of amputation in patients with diabetes mellitus and peripheral artery disease. Arteriosclerosis, thrombosis, and vascular biology, 40(8), 1808-17. DOI: 10.1161/ATVBAHA.120.314595
6. Cao M, Zhang D, Wang Y, Lu Y, Zhu X, Li Y, et al. (2020). Clinical features of patients infected with the novel coronavirus (CV) in Shanghai, China. MedRxiv. DOI: 10.1101/2020.03.04.20030395.
7. Chen M, Fan Y, Wu X, Zhang L, Guo T, Deng K, Cao J, Luo H, He T, Gong Y & Wang H (2019). Clinical characteristics and risk factors for fatal outcome in patients with -oronavirus infected disease (CV) in Wuhan China. DOI: 10.2139/ssrn.3546069.
8. Dal Canto E, Ceriello A, Rydén L, Ferrini M, Hansen TB, Schnell O, Standl E & Beulens JW (2019). Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications. European journal of preventive cardiology, 26(2_suppl), 25-32. DOI: 10.1177/2047487319878371
9. Feng Z, Yu Q, Yao S, Luo L, Duan J, Yan Z, et al (2020). Early prediction of disease progression in novel coronavirus pneumonia patients outside Wuhan with CT and clinical characteristics. MedRxiv DOI:10.1101/2020.02.19.20025296.
10. Fu L, Fei J, Xiang HX, Xiang Y, Tan ZX, Li MD, Liu FF, Liu HY, Zheng L, Li Y & Zhao H (2020). Analysis of death risk factors among 200 CVpatients in Wuhan, China a hospital-based case-cohort study. Fang-Fang and Liu, Hong-Yan and Zheng, Ling and Li, Ying and Zhao, Hui and Xu, De-Xiang, Analysis of Death Risk Factors Among 200. DOI: 10.2139/ssrn.3551430.
11. Genco RJ, Graziani F & Hasturk H (2020). Effects of periodontal disease on glycemic control, complications, and incidence of diabetes mellitus. Periodontology, 83(1), 59-65.DOI: 10.1111/prd.12271
12. Glovaci D, Fan W & Wong ND (2019). Epidemiology of diabetes mellitus and cardiovascular disease. Current cardiology reports, 21, 1-8. DOI: 10.1007/s11886-019-1107-y
13. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DS & Du B (2020). Clinical characteristics of coronavirus disease in China. New England journal of medicine, 382(18), 1708-20. DOI: 10.1056/NEJMoa2002032.
14. Hui H, Zhang Y, Yang X, Wang X, He B, Li L, Li H, Tian J & Chen Y (2020). Clinical and radiographic features of cardiac injury in patients with 2019 novel coronavirus pneumonia MedRxiv 2020-02.DOI: 10.1101/2020.02.24.20027052.
15. Li K, Chen D, Chen S, Feng Y, Chang C, Wang Z, Wang N & Zhen G (2020). Radiographic findings and other predictors in adults with CV. MedRxiv 2020-03. DOI: 10.1101/2020.03.23.20041673.
16. Li Q, Ling Y, Zhang J, Li W, Zhang X, Jin Y, Li L, Fu Q, Huang Y, Lu H & Chen L (2020). Clinical characteristics of SARS-CoV-2 infections involving 325 hospitalized patients outside Wuhan. DOI: 10.21203/rs.3.rs-18699/v1.
17. Liu J, Liu Y, Xiang P, Pu L, Xiong H, Li C, Zhang M, Tan J, Xu Y, Song R & Song M (2020). Neutrophil-to-lymphocyte ratio predicts severe illness patients with novel coronavirus in the early stage. MedRxiv.DOI: 10.1101/2020.02.10.20021584
18. Liu W, Tao Z-W, Lei W, Ming-Li Y, Kui L, Ling Z, et al (2020). Analysis of factors associated with disease outcomes in hospitalized patients with novel coronavirus disease. Chin Med J (Engl) 1. DOI: 10.1097/ cm9.0000000000000775.
19. Meawed TE, Ahmed SM, Mowafy SM, Samir GM & Anis RH (2021). Bacterial and fungal ventilator associated pneumonia in critically ill CVpatients during the second wave. Journal of infection and public health, 14(10), 1375-80. DOI: 10.1016/j.jiph.2021.08.003.
20. Nasir N, Farooqi J, Mahmood SF & Jabeen K (2020). COVID‐19‐associated pulmonary aspergillosis (CAPA) in patients admitted with severe COVID‐19 pneumonia: an observational study from Pakistan. Mycoses, 63(8), 766-70. DOI: 10.1111/myc.13135.
21. Oriot P & Hermans MP (2022) Euglycemic diabetic ketoacidosis in a patient with type 1 diabetes and SARS-CoV-2 pneumonia case-report and review of the literature ActaClinicaBelgica, 77(1), 113-7. DOI: 10.1080/17843286.2020.1780390.
22. Pranata R, Lim MA, Huang I, Raharjo SB & Lukito AA (2020). Hypertension is associated with increased mortality and severity of disease in CVpneumonia: a systematic review, meta-analysis and meta-regression. Journal of the renin-angiotensin-aldosterone system JRAA, 21(2), DOI: 10.1177/1470320320926899.
23. Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al (2020) Dysregulation of immune response in patients with CVin Wuhan, China. Clin Infect Dis 53 1689e99. DOI: 10.1093/cid/ciaa248.
24. Segrelles‐Calvo G, Araújo GR, Llopis‐Pastor E, Carrillo J, Hernández‐Hernández M, Rey L, Rodríguez Melean N, Escribano I, Antón E, Zamarro C & García‐Salmones M (2021) Prevalence of opportunistic invasive aspergillosis in COVID‐19 patients with severe pneumonia. Mycoses, 64(2), 144-51. DOI: 10.1111/myc.13219.
25. Sholzberg M, Tang GH, Rahhal H, AlHamzah M, Kreuziger LB, Áinle FN, Alomran F, Alayed K, Alsheef M, AlSumait F, Pompilio CE. Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial. Bmj 375. DOI: 10.1136/bmj.n2400
26. Stam HJ, Stucki G & Bickenbach J (2020). Covid-19 and post intensive care syndrome: a call for action. Journal of rehabilitation medicine, 52(4). DOI: 10.2340/16501977-2677.
27. von der Thüsen J & van der Eerden M (2020). Histopathology and genetic susceptibility in COVID‐19 pneumonia. European journal of clinical investigation, 50(7), e13259. DOI: 10.1111/eci.13259.
28. Wan Y, Shang J, Graham R, Baric RS & Li F (2020). Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long Structural studies of SARS coronavirus. J Virol, 94, 1e9. DOI: 10.1128/jvi.00127 20.
29. Wang D,LiR,WangJ,Jiang Q, Gao C, Yang J, et al (2020). Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of CVin Wuhan, China: a descriptive study. Res Sq n.d.:1e17. DOI: 10.21203/rs.3.rs-19680/v1
30. Wang Z & Wang Z (2021). Identification of risk factors for in-hospital death of CVpneumonia--lessions from the early outbreak BMC. Infectious Diseases, 21(1), 1-0. DOI: 10.1186/s12879-021-05814-4.
31. Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al (2020). Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease pneumonia in Wuhan, China. JAMA Intern Med 1e10. DOI: 10.1001/jamainternmed.2020.0994.
32. Yuan B, Chen Y, Wang J, Wang C, Song S & Liu H-Q (2020). Epidemiological Characteristics of 417 patients infected with CVand 368 discharged cases among them in Shenzhen City, China CURRENT STATUS under review. Res Sq 1e14. DOI: 10.21203/rs.3.rs-19554/v1.
33. Yuan M, Yin W, Tao Z, Tan W & Hu Y (2020). Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China PloS one, 15(3), e0230548. DOI: 10.1371/journal.pone.0230548.
34. Zhang J jin, Dong X, Cao Y yuan, Yuan Y dong, Yang Y bin, qin Yan Y, et al (2020). Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy Eur J Allergy ClinImmunol 1e12. DOI: https://doi.org/10.1111/ all.14238.
35. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X & Guan L (2020). Clinical course and risk factors for mortality of adult inpatients with CVin Wuhan, China: a retrospective cohort study. The lancet, 395(10229), 1054-62. DOI: https://doi.org/10.1016/S0140-6736(20)30566-3.

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How to cite

Ganapathy, K., Mishra, S., Kapoor, E., & Patel, D. J. (2024). Diabetes mellitus patients with increased death rates and clinical complications in patients with CoV-19 pneumonia: A systematic review. Multidisciplinary Reviews, 6, 2023ss007. https://doi.org/10.31893/multirev.2023ss007

[1] Ahmadikia K, Hashemi SJ, Khodavaisy S, Getso MI, Alijani N, Badali H, Mirhendi H, Salehi M, Tabari A, MohammadiArdehali M & Kord M (2021). The double‐edged sword of systemic corticosteroid therapy in viral pneumonia A case report and comparative review of influenza‐associated mucormycosis versus COVID‐19 associated mucormycosis. Mycoses, 64(8), 798-808. DOI: 10.1111/myc.13256.

[2] Ahmed N, Mahmood MS, Ullah MA, Araf Y, Rahaman TI, Moin AT & Hosen MJ (2022). COVID-19-associated candidiasis: possible patho-mechanism, predisposing factors, and prevention strategies. Current Microbiology, 79(5), 127. DOI: 10.1007/s00284-022-02824-6.

[3] Al-kuraishy HM, Al-Maiahy TJ, Al-Gareeb AI, Musa RA & Ali ZH (2020). CV pneumonia in an Iraqi pregnant woman with preterm delivery. Asian Pacific Journal of Reproduction, 9(3), 156-8. DOI: 10.4103/2305-0500.282984

[4] Baqi S, Naz A, Sayeed MA, Khan S, Ismail H, Kumar V, Somjimal H, Aneela J, Imtiaz S, Aftab S & Kumar V (2021). Clinical characteristics and outcome of patients with severe CVpneumonia at a public sector hospital in Karachi, Pakistan. Cureus, 13(2). DOI: 10.7759/cureus.13107.

[5] Barnes JA, Eid MA, Creager MA & Goodney PP (2020). Epidemiology and risk of amputation in patients with diabetes mellitus and peripheral artery disease. Arteriosclerosis, thrombosis, and vascular biology, 40(8), 1808-17. DOI: 10.1161/ATVBAHA.120.314595

[6] Cao M, Zhang D, Wang Y, Lu Y, Zhu X, Li Y, et al. (2020). Clinical features of patients infected with the novel coronavirus (CV) in Shanghai, China. MedRxiv. DOI: 10.1101/2020.03.04.20030395.

[7] Chen M, Fan Y, Wu X, Zhang L, Guo T, Deng K, Cao J, Luo H, He T, Gong Y & Wang H (2019). Clinical characteristics and risk factors for fatal outcome in patients with -oronavirus infected disease (CV) in Wuhan China. DOI: 10.2139/ssrn.3546069.

[8] Dal Canto E, Ceriello A, Rydén L, Ferrini M, Hansen TB, Schnell O, Standl E & Beulens JW (2019). Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications. European journal of preventive cardiology, 26(2_suppl), 25-32. DOI: 10.1177/2047487319878371

[9] Feng Z, Yu Q, Yao S, Luo L, Duan J, Yan Z, et al (2020). Early prediction of disease progression in novel coronavirus pneumonia patients outside Wuhan with CT and clinical characteristics. MedRxiv DOI:10.1101/2020.02.19.20025296.

[10] Fu L, Fei J, Xiang HX, Xiang Y, Tan ZX, Li MD, Liu FF, Liu HY, Zheng L, Li Y & Zhao H (2020). Analysis of death risk factors among 200 CVpatients in Wuhan, China a hospital-based case-cohort study. Fang-Fang and Liu, Hong-Yan and Zheng, Ling and Li, Ying and Zhao, Hui and Xu, De-Xiang, Analysis of Death Risk Factors Among 200. DOI: 10.2139/ssrn.3551430.

[11] Genco RJ, Graziani F & Hasturk H (2020). Effects of periodontal disease on glycemic control, complications, and incidence of diabetes mellitus. Periodontology, 83(1), 59-65.DOI: 10.1111/prd.12271

[12] Glovaci D, Fan W & Wong ND (2019). Epidemiology of diabetes mellitus and cardiovascular disease. Current cardiology reports, 21, 1-8. DOI: 10.1007/s11886-019-1107-y

[13] Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DS & Du B (2020). Clinical characteristics of coronavirus disease in China. New England journal of medicine, 382(18), 1708-20. DOI: 10.1056/NEJMoa2002032.

[14] Hui H, Zhang Y, Yang X, Wang X, He B, Li L, Li H, Tian J & Chen Y (2020). Clinical and radiographic features of cardiac injury in patients with 2019 novel coronavirus pneumonia MedRxiv 2020-02.DOI: 10.1101/2020.02.24.20027052.

[15] Li K, Chen D, Chen S, Feng Y, Chang C, Wang Z, Wang N & Zhen G (2020). Radiographic findings and other predictors in adults with CV. MedRxiv 2020-03. DOI: 10.1101/2020.03.23.20041673.

[16] Li Q, Ling Y, Zhang J, Li W, Zhang X, Jin Y, Li L, Fu Q, Huang Y, Lu H & Chen L (2020). Clinical characteristics of SARS-CoV-2 infections involving 325 hospitalized patients outside Wuhan. DOI: 10.21203/rs.3.rs-18699/v1.

[17] Liu J, Liu Y, Xiang P, Pu L, Xiong H, Li C, Zhang M, Tan J, Xu Y, Song R & Song M (2020). Neutrophil-to-lymphocyte ratio predicts severe illness patients with novel coronavirus in the early stage. MedRxiv.DOI: 10.1101/2020.02.10.20021584

[18] Liu W, Tao Z-W, Lei W, Ming-Li Y, Kui L, Ling Z, et al (2020). Analysis of factors associated with disease outcomes in hospitalized patients with novel coronavirus disease. Chin Med J (Engl) 1. DOI: 10.1097/ cm9.0000000000000775.

[19] Meawed TE, Ahmed SM, Mowafy SM, Samir GM & Anis RH (2021). Bacterial and fungal ventilator associated pneumonia in critically ill CVpatients during the second wave. Journal of infection and public health, 14(10), 1375-80. DOI: 10.1016/j.jiph.2021.08.003.

[20] Nasir N, Farooqi J, Mahmood SF & Jabeen K (2020). COVID‐19‐associated pulmonary aspergillosis (CAPA) in patients admitted with severe COVID‐19 pneumonia: an observational study from Pakistan. Mycoses, 63(8), 766-70. DOI: 10.1111/myc.13135.

[21] Oriot P & Hermans MP (2022) Euglycemic diabetic ketoacidosis in a patient with type 1 diabetes and SARS-CoV-2 pneumonia case-report and review of the literature ActaClinicaBelgica, 77(1), 113-7. DOI: 10.1080/17843286.2020.1780390.

[22] Pranata R, Lim MA, Huang I, Raharjo SB & Lukito AA (2020). Hypertension is associated with increased mortality and severity of disease in CVpneumonia: a systematic review, meta-analysis and meta-regression. Journal of the renin-angiotensin-aldosterone system JRAA, 21(2), DOI: 10.1177/1470320320926899.

[23] Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al (2020) Dysregulation of immune response in patients with CVin Wuhan, China. Clin Infect Dis 53 1689e99. DOI: 10.1093/cid/ciaa248.

[24] Segrelles‐Calvo G, Araújo GR, Llopis‐Pastor E, Carrillo J, Hernández‐Hernández M, Rey L, Rodríguez Melean N, Escribano I, Antón E, Zamarro C & García‐Salmones M (2021) Prevalence of opportunistic invasive aspergillosis in COVID‐19 patients with severe pneumonia. Mycoses, 64(2), 144-51. DOI: 10.1111/myc.13219.

[25] Sholzberg M, Tang GH, Rahhal H, AlHamzah M, Kreuziger LB, Áinle FN, Alomran F, Alayed K, Alsheef M, AlSumait F, Pompilio CE. Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial. Bmj 375. DOI: 10.1136/bmj.n2400

[26] Stam HJ, Stucki G & Bickenbach J (2020). Covid-19 and post intensive care syndrome: a call for action. Journal of rehabilitation medicine, 52(4). DOI: 10.2340/16501977-2677.

[27] von der Thüsen J & van der Eerden M (2020). Histopathology and genetic susceptibility in COVID‐19 pneumonia. European journal of clinical investigation, 50(7), e13259. DOI: 10.1111/eci.13259.

[28] Wan Y, Shang J, Graham R, Baric RS & Li F (2020). Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long Structural studies of SARS coronavirus. J Virol, 94, 1e9. DOI: 10.1128/jvi.00127 20.

[29] Wang D,LiR,WangJ,Jiang Q, Gao C, Yang J, et al (2020). Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of CVin Wuhan, China: a descriptive study. Res Sq n.d.:1e17. DOI: 10.21203/rs.3.rs-19680/v1

[30] Wang Z & Wang Z (2021). Identification of risk factors for in-hospital death of CVpneumonia--lessions from the early outbreak BMC. Infectious Diseases, 21(1), 1-0. DOI: 10.1186/s12879-021-05814-4.

[31] Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al (2020). Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease pneumonia in Wuhan, China. JAMA Intern Med 1e10. DOI: 10.1001/jamainternmed.2020.0994.

[32] Yuan B, Chen Y, Wang J, Wang C, Song S & Liu H-Q (2020). Epidemiological Characteristics of 417 patients infected with CVand 368 discharged cases among them in Shenzhen City, China CURRENT STATUS under review. Res Sq 1e14. DOI: 10.21203/rs.3.rs-19554/v1.

[33] Yuan M, Yin W, Tao Z, Tan W & Hu Y (2020). Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China PloS one, 15(3), e0230548. DOI: 10.1371/journal.pone.0230548.

[34] Zhang J jin, Dong X, Cao Y yuan, Yuan Y dong, Yang Y bin, qin Yan Y, et al (2020). Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy Eur J Allergy ClinImmunol 1e12. DOI: https://doi.org/10.1111/ all.14238.

[35] Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X & Guan L (2020). Clinical course and risk factors for mortality of adult inpatients with CVin Wuhan, China: a retrospective cohort study. The lancet, 395(10229), 1054-62. DOI: https://doi.org/10.1016/S0140-6736(20)30566-3.

Abstract

References

How to cite