Alpha Lipoic Acid (ALA) is a fatty acid that mainly synthases mammals and plants. Alpha lipoic acid is found in trace amounts, soluble in water and fat. ALA plays an essential role in the body's synthases of glutathione, the body's most important endogenous antioxidant, supporting healthy vision, protecting cells from free radicals, and enhancing liver functions. Additionally, ALA helps dissolve toxic substances in the liver. In the present review, we described the history with the physical and biochemical properties of ALA besides highlighting its functions in living organisms. We also reviewed the benefits of using synthetic forms of ALA in domestic animals to prevent and treat medical disorders. In conclusion, in addition to its role in enhancing body functions, ALA also plays a major role as a valuable antioxidant that could give an advantage to its use as a promising treatment against the widespread infection in animals and humans.