The effect of Hsp90 gene polymorphism on the beef cattle production: a review paper

Authors

  • Hassan Nima Habib Department of Animal Production, College of Agriculture, University of Basrah, Iraq.
  • Wessam Monther Mohammed Saleh Department of Internal and Preventive Medicine, College of Veterinary Medicine, University of Basrah, Basra State, Iraq.
  • Qutaiba J. Gheni Department of Animal Production, College of Agriculture, University of Basrah, Iraq.
  • Alfred S. Karomy Department of Animal Production, College of Agriculture, University of Basrah, Iraq.

DOI:

https://doi.org/10.29327/multi.2021020

Keywords:

Hsp90 gene, polymorphism, heat stress, beef cattle

Abstract

Beef cattle production is a worthwhile worldwide industry that faces many challenges, such as environmental heat stress, which leads to severe economic losses. As part of the heat shock proteins group, Heat Shock Protein 90 (HSP90) is a molecular chaperone common to all eukaryotic cells. It helps to protect cells from damage caused by heat shock. Reviewing polymorphisms of the HSP90 gene and their relationship with beef production was the purpose of this article. We described the structure of the HSP90 and its functions on living cells during adaptation to stress conditions. We also evaluated the HSP90 gene expression role and its polymorphisms on heat stress reaction in livestock. In conclusion, all livestock, especially cattle, are sensitive to heat stress depending on the amount of polymorphism in the hsp90 gene. Under heat stress conditions, HSP 90 and its polymorphism increase cell survivability and regulate body temperature.

References

Alard JE, Pers JO, Youinou P, Jamin C (2014) Heat Shock Protein Autoantibodies. In Autoantibodies (pp. 343-348). Elsevier.‏

Al-Samea MBA, Ali MF (2014) Geographic Analysis of the Livestock in Iraq and its Natural and biotic problems and its development potentialities. Adab Al-Kufa, 1(18).‏

Ajayi OO, Peters SO, De Donato M, Sowande SO, Mujibi FD, Morenikeji OB, Imumorin IG (2018) Computational genome-wide identification of heat shock protein genes in the bovine genome. F1000Research, 7.‏

Archana PR, Aleena J, Pragna P, Vidya MK, Niyas APA, Bagath M, ... Bhatta R (2017) Role of heat shock proteins in livestock adaptation to heat stress. J Dairy Vet Anim Res 5:00127.‏

Badri TM, Chen KL, Alsiddig MA, Li L, Cai Y, Wang GL (2018) Genetic polymorphism in Hsp90AA1 gene is associated with the thermotolerance in Chinese Holstein cows. Cell Stress and Chaperones 23:639-651.‏

Bernabucci U (2019) Climate change: impact on livestock and how can we adapt. Animal frontiers: the review magazine of animal agriculture 9:3.‏

Carabaño MJ, Ramón M, Menéndez-Buxadera A, Molina A, Díaz C (2019) Selecting for heat tolerance. Animal Frontiers 9:62-68.‏

Ciocca DR, Arrigo AP, Calderwood SK (2013) Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update. Archives of toxicology 87:19-48.‏

Coffel ED, Horton RM, De Sherbinin A (2017) Temperature and humidity based projections of a rapid rise in global heat stress exposure during the 21st century. Environmental Research Letters 13:014001.‏

Daturpalli S, Waudby CA, Meehan S, Jackson SE (2013) Hsp90 inhibits α-synuclein aggregation by interacting with soluble oligomers. Journal of molecular biology 425:4614-4628.‏

Datta K, Rahalkar K, Dinesh DK (2017) Heat Shock Proteins (Hsp): Classifications and Its Involvement in Health and Disease. J Pharma Care Health Sys 4:175.

Didenko T, Duarte AM, Karagöz GE, Rüdiger SG (2012) Hsp90 structure and function studied by NMR spectroscopy. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823:636-647.‏

Elsasser TH, Li CJ, Shaffer J, Collier RJ (2012) Effects of environment on animal health: mechanisms and regulatory inputs. In Environmental physiology of livestock (pp. 129-164). Oxford, UK: Wiley-Blackwell.‏

Finney A (2018) Relationships among beef cow productivity traits and single nucleotide polymorphisms in the bovine heat shock protein 70 gene.‏

Jackson SE (2012) Hsp90: structure and function. Molecular chaperones 155-240.‏

Johnson JS (2018) Heat stress: impact on livestock well-being and productivity and mitigation strategies to alleviate the negative effects. Animal Production Science 58:1404-1413.‏

Habib HN, Hassan AF, Khudaier BY (2017) Molecular detection of polymorphism of heat shock protein 70 (hsp70) in the semen of Iraqi Holstein bulls. Asian J Anim Sci 11:132-139.‏

Habib HN, Khudaier BY, Hassan AF (2018) Molecular Detection of Polymorphism of Heat Shock Protein 70 (hsp70) in the Semen of Arabi Rams. Basrah Journal of Veterinary Research 17:3.‏

Habib HN, Khudaier BY, Hassan AF., Saleh WM (2018) The association of the polymorphism and gene expression of heat shock protein hsp70 gene in winter and summer in the semen of holstein bulls born in iraq. Basrah Journal of Veterinary Research 17:3.‏

Habib HN, Karomy AS, Gheni QJ, Saleh WMM (2020, November). Molecular detected of heat shock protein70 gene in Layer hens (Lohmann breed). In IOP Conference Series: Materials Science and Engineering (Vol. 928, No. 6, p. 062017). IOP Publishing.‏

Habib HN (2020) Molecular characterization of heat shock protein 70 gene in Iraqi buffalo. Iraqi Journal of Veterinary Sciences 34:139-143.‏

Hartl FU, Bracher A, Hayer-Hartl M (2011) Molecular chaperones in protein folding and proteostasis. Nature 475:324-332.‏

Hillman PE, Gebremedhin KG, Willard ST, Lee CN, Kennedy AD (2009) Continuous measurements of vaginal temperature of female cattle using a data logger encased in a plastic anchor. Applied Engineering in agriculture 25:291-296.‏

Hoter A, El-Sabban ME, Naim HY (2018) The HSP90 family: structure, regulation, function, and implications in health and disease. International journal of molecular sciences 19:2560.‏

Hu H, Zhang Y, Zheng N, Cheng J, Wang J (2016) The effect of heat stress on gene expression and synthesis of heat‐shock and milk proteins in bovine mammary epithelial cells. Animal Science Journal 87:84-91.‏

Idris M, Uddin J, Sullivan M, McNeill DM, Phillips CJ (2021) Non-Invasive Physiological Indicators of Heat Stress in Cattle. Animals 11:71.‏

Galal A, Radwan LM (2020) Identification of single nucleotide polymorphism in heat shock protein HSP70 and HSP90 after four selection generations in two lines of chickens. Annals of Agricultural Sciences 65:124-128.‏

Gaughan JB, Sejian V, Mader TL, Dunshea FR (2019) Adaptation strategies: ruminants. Animal Frontiers 9:47-53.‏

Goetz MP, Toft DO, Ames MM, Erlichman C (2003) The Hsp90 chaperone complex as a novel target for cancer therapy. Annals of oncology 14:1169-1176.‏

Grad I, Picard D (2007) The glucocorticoid responses are shaped by molecular chaperones. Molecular and cellular endocrinology 275:2-12.‏

Crevel G, Bates H, Huikeshoven H, Cotterill S (2001) The Drosophila Dpit47 protein is a nuclear Hsp90 co-chaperone that interacts with DNA polymerase α. Journal of cell science, 114(11), 2015-2025.‏

Kovács L, Kézér L, Tőzsér J (2013) Measuring stress level of dairy cows during milking using by geometric indices of heart rate variability. Scientific Papers Animal Science and Biotechnologies, 46(1), 213-217.‏

Krause SW, Gastpar R, Andreesen R, Gross C, Ullrich H, Thonigs G, Multhoff G (2004) Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase I trial. Clinical Cancer Research, 10(11), 3699-3707.

Kumar R, Gupta ID, Verma A, Verma N, Vineeth MR (2015) Genetic polymorphisms within exon 3 of heat shock protein 90AA1 gene and its association with heat tolerance traits in Sahiwal cows. Veterinary world, 8(7), 932.‏

Kumar R, Gupta ID, Verma A, Singh SV, Verma N, Vineeth MR, ... Das R (2016) Novel SNP identification in exon 3 of HSP90AA1 gene and their association with heat tolerance traits in Karan Fries (Bos taurus× Bos indicus) cows under tropical climatic condition. Tropical animal health and production, 48(4), 735-740.‏

Lacerda TF, Loureiro B (2015) Selecting thermotolerant animals as a strategy to improve fertility in Holstein cows. Global Journal of Animal Scientific Research 3:119-127.‏

Lees AM (2016) Biological responses of feedlot cattle to heat load (Doctoral dissertation, PhD thesis. School of Agriculture and Food Sciences, University of Queensland).‏

Liu S, Yue T, Ahmad MJ, Hu X, Zhang X, Deng T, ... Yang L (2020) Transcriptome analysis reveals potential regulatory genes related to heat tolerance in holstein dairy cattle. Genes 11:68.‏

Mader T L, Davis MS, Brown-Brandl T (2006) Environmental factors influencing heat stress in feedlot cattle. Journal of Animal Science, 84(3), 712-719.‏

‏Mshaik R, Simonet J, Georgievski A, Jamal L, Bechoua S, Ballerini P, Quéré R (2021) HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias. Blood cancer journal 11:1-15.‏

Nadeem A, Javed M, Hassan FU, Luo X, Khalid RB, Liu Q (2020) Genomic identification, evolution and sequence analysis of the heat-shock protein gene family in buffalo. Genes, 11(11), 1388.‏

Nienaber JA, Hahn GL (2007) Livestock production system management responses to thermal challenges. International Journal of Biometeorology 52:149-157.‏

Onasanya GO, Ikeobi CO, Ayotunde AS, Oke FO, Olorunisola RA, Decampos JS (2017) Thermo-Regulatory Functions of Heat Shock Protein Genes in Some Selected Tropically Stressed Livestock Animals. Int J Appl Res Technol 6:37–43.

Onasanya GO, Msalya GM, Thiruvenkadan AK, Sreekumar C, Tirumurugaan GK, Fafiolu AO, Okpeku M (2020a) Heterozygous Single-Nucleotide Polymorphism Genotypes at Heat Shock Protein 70 Gene Potentially Influence Thermo-Tolerance Among Four Zebu Breeds of Nigeria. Frontiers in Genetics 12:391.

Onasanya GO, Thiruvenkadan AK, Sreekumar C, Tirumurugaan GK, Msalya GM, Sanni M T, ... Ikeobi CO (2020b) SINGLE NUCLEOTIDE POLYMORPHISM-BASE CHARACTERIZATION OF HSP 90A1A GENE IN SOME NIGERIAN CATTLE BREEDS. Young.‏

Osei-Amponsah R, Chauhan SS, Leury BJ, Cheng L, Cullen B, Clarke I J, Dunshea F R (2019) Genetic selection for thermotolerance in ruminants. Animals, 9:948.‏

‏Pałyga J, Kozłowski Ł (2007) Structure and function of molecular chaperone HSP90.‏

Pires ES, Khole VV (2009) A block in the road to fertility: autoantibodies to heat-shock protein 90-β in human ovarian autoimmunity. Fertility and sterility 92:1395-1409.‏

Pires ES, Choudhury AK, Idicula-Thomas S, Khole VV (2011) Anti-HSP90 autoantibodies in sera of infertile women identify a dominant, conserved epitope EP6 (380-389) of HSP90 beta protein. Reproductive Biology and Endocrinology, 9(1), 1-13.‏

Prodromou C (2003) Pearl LH. Structure and functional relationships of Hsp90. Curr Cancer Drug Targets, 3, 301-323.‏

Ranek MJ, Stachowski MJ, Kirk JA, Willis MS (2018) The role of heat shock proteins and co-chaperones in heart failure. Philosophical Transactions of the Royal Society B: Biological Sciences, 373(1738), 20160530.‏

Raza SHA, Hassanin AA, Dhshan AI, Abdelnour SA, Khan R, Mei C, Zan L(2021) In silico genomic and proteomic analyses of three heat shock proteins (HSP70, HSP90-α, and HSP90-β) in even-toed ungulates. Electronic Journal of Biotechnology 53:61-70.‏

Reshma RS, Das DN (2021) Molecular markers and its application in animal breeding. In Advances in Animal Genomics (pp. 123-140). Academic Press.‏

Richter K, Haslbeck M, Buchner J (2010) The heat shock response: life on the verge of death. Molecular cell 40:253-266.‏

Rotz CA, Asem-Hiablie S, Dillon J, Bonifacio H (2015) Cradle-to-farm gate environmental footprints of beef cattle production in Kansas, Oklahoma, and Texas. Journal of animal science 93:2509-2519.‏

Sackett D, Holmes P, Abbot K, Jephcott S, Barber M (2006) Assessing the economic cost of endemic disease on the profitability of Australian beef cattle and sheep producers. Report no. AHW.087. Meat and Livestock Australia, Sydney, NSW, Australia.

Scharf B A (2008) Comparison of thermoregulatory mechanisms in heat sensitive and tolerant breeds of Bos taurus cattle. University of Missouri-Columbia.‏

Schopf FH, Biebl MM, Buchner J (2017) The HSP90 chaperone machinery. Nature reviews Molecular cell biology, 18(6), 345-360.‏

Singh KM, Singh S, Ganguly I, Nachiappan R K, Ganguly A, Venkataramanan R, Narula HK (2017) Association of heat stress protein 90 and 70 gene polymorphism with adaptability traits in Indian sheep (Ovis aries). Cell Stress and Chaperones 22:675-684.‏

Smith GG (2018) Polymorphisms of Bovine HSP90 and Their Implications in Beef Cattle Productivity.‏

Sreedhar AS, Kalmár É, Csermely P, Shen YF (2004) Hsp90 isoforms: functions, expression and clinical importance. FEBS letters 562:11-15.‏

St-Pierre NR, Cobanov B, Schnitkey G (2003) Economic losses from heat stress by US livestock industries. Journal of dairy science 86:E52-E77.‏

Summer A, Lora I, Formaggioni P, Gottardo F (2019) Impact of heat stress on milk and meat production. Animal Frontiers 9:39-46.‏

Taipale M, Jarosz DF, Lindquist S (2010) HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nature reviews Molecular cell biology 11:515-528.‏

USDA (2015) Cattle & Beef: Statistics & Information. Retrieved from https://www.ers.usda.gov/topics/animal-products/cattle-beef/statistics-information/

Wan Y, Ma C, Wei P, Fang Q, Guo X, Zhou B, Jiang R (2017) Dynamic expression of HSP90B1 mRNA in the hypothalamus of two Chinese chicken breeds under heat stress and association analysis with a SNP in Huainan chickens. Czech Journal of Animal Science 62:82-87.‏

Wandinger SK, Richter K, Buchner J (2008) The Hsp90 chaperone machinery. Journal of Biological Chemistry 283:18473-18477.‏

Wang X, Chen M, Zhou J, Zhang X (2014) HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy. International journal of oncology 45:18-30.‏

Whitesell L, Lindquist S L (2005) HSP90 and the chaperoning of cancer. Nature Reviews Cancer 5:761-772.‏

Xu F, Shan S, Sommerlad S, Seddon JM, Brenig B (2021) A Missense Mutation in the KLF7 Gene Is a Potential Candidate Variant for Congenital Deafness in Australian Stumpy Tail Cattle Dogs. Genes 12:467.‏

Yadav P, Yadav B, Swain D K, Anand M, Yadav S, Madan A K (2021) Differential expression of miRNAs and related mRNAs during heat stress in buffalo heifers. Journal of Thermal Biology 97:102904.‏

Yang C, Wang L, Liu C, Zhou Z, Zhao X, Song L (2015) The polymorphisms in the promoter of HSP90 gene and their association with heat tolerance of bay scallop. Cell Stress and Chaperones 20:297-308.‏

Zhu H, Liu J, Chakraborty C, Chen L (2015) Analysing the effect of mutation on protein function and discovering potential inhibitors of CDK4: molecular modelling and dynamics studies. PLoS One 10:e0133969.

Downloads

Published

2021-10-30

How to Cite

Habib, H. N., Saleh, . W. M. M., Gheni, Q. J. ., & Karomy, A. S. (2021). The effect of Hsp90 gene polymorphism on the beef cattle production: a review paper. Multidisciplinary Reviews, 4, e2021020. https://doi.org/10.29327/multi.2021020

Issue

Section

Review Article

Most read articles by the same author(s)