Administration of curcumin affects the anxiety behavior in Wistar rats after formaldehyde injected

Authors

  • Mouna Nouacer Applied Neuroendocrinology Laboratory, Department of Biology, Faculty of Sciences, University Badji Mokhtar, Annaba, Algeria. https://orcid.org/0000-0001-7589-8191
  • Amira Bakeche Applied Neuroendocrinology Laboratory, Department of Biology, Faculty of Sciences, University Badji Mokhtar, Annaba, Algeria. https://orcid.org/0000-0002-9024-138X
  • Ibtissem Chouba Applied Neuroendocrinology Laboratory, Department of Biology, Faculty of Sciences, University Badji Mokhtar, Annaba, Algeria.
  • Abdelkrim Tahraoui Applied Neuroendocrinology Laboratory, Department of Biology, Faculty of Sciences, University Badji Mokhtar, Annaba, Algeria. https://orcid.org/0000-0002-4855-4112

Keywords:

animal behavior, anxiety, Curcuma longa, open-field test, tumeric

Abstract

The curcumin is part of the curcuminoids family. Present in the spice turmeric is a vegetable alkaloid obtained from Curcuma longa. Many studies have been carried out to describe the multiple biological actions of curcumin. The positive antidepressant and anti-anxiety effects of curcumin are most likely due to its ability to normalize specific physiological mechanisms, in addition to being a potent antioxidant and anti-inflammatory agent. Curcumin also protects the brain and simultaneously acts on several mechanisms related to depression. It is considered to be the most promising therapeutic target for treating depressive behaviors. Through this work, we will prove the protective effect of curcumin on the anxious behavior of Wistar rats and the complications induced by the administration of a toxic product that is formaldehyde. To this fact, 25 white rats of Wistar strains (250±50 g) were separated into five experimental batches: control batch (T; n = 5), vehicle control batch (CV; n = 5), Curcumin control batch (CC; n = 5), one batch formaldehyde vehicle (FV; n = 5) and one batch formaldehyde Curcumin (FC; n = 5). A single intraperitoneal injection carried out the formaldehyde administration diluted in distilled water at a dose of 10 mg/kg. Turmeric dissolved in olive oil was administered by gastric gavage at a dose of (60 mg/kg). Our results show the therapeutic benefits of curcumin against the deficits caused by formaldehyde reflected in a disturbance in rat behavior and degree of anxiety using the open-field test and the light and dark box test.

Time spent in the peripheral zone and the central zone of the open field of the batches: controls (T), vehicle control (CV), Curcumin control (CC), vehicle formaldehyde (FV), and curcumin formaldehyde (FC) the results are expressed as mean±SEM. Ns. is non-significant difference = P > 0.05 ; * P <0.05 ; ** P <0.01; *** P <0.001.

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CITATION

PUBLISHED: 2021-04-29

How to Cite

Nouacer, M., Bakeche, A., Chouba, . I., & Tahraoui, A. (2021). Administration of curcumin affects the anxiety behavior in Wistar rats after formaldehyde injected. Journal of Animal Behaviour and Biometeorology, 9(3), 2127. Retrieved from https://malque.pub/ojs/index.php/jabb/article/view/89

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Section

Research Article

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