Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats

Fella Boudiaf; Ibtissem Chouba; Naziha Amri; Abdelkarim Tahraoui

Keywords:

antioxidants

anxiety

diabetes

Abstract

We aim was to evaluate the protective effects of the antioxidants cinnamon and quercetin on neurobehavioral alterations and complications, besides biochemical parameters of induced-diabetics Wistar rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin at a dose of (45 mg/kg). The administration of streptozotocin was considered acting on anxiety behaviors and biochemical parameters in adult Wistar rats. On the other hand, the protective role of antioxidants (cinnamon and quercetin) on streptozotocin-induced disorders was also evaluated. Behavioral tests in the open field (OF) revealed that diabetic animals exhibited an anxious behavior and an alteration in the locomotive and exploratory activities when compared to control. The administration of the cinnamon (2g/kg) and Quercetin (0.5g/kg) by gastric gavage reduces anxiety and decreases hyperglycemia-related harm. However, antioxidants cinnamon and quercetin administration significantly alleviated anxious and depressive behaviors.
References
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2. Aggarwal BB, Sung B (2009) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern tragets trend pharmacol. Science 30:85-94
3. Anderson P, Phillips K, Stoecklin G, Kedersha N (2004) Post-transcriptional regulation of proinflammatory proteins. Journal of Leukocyte Biology 76:42-47.
4. Broadhurst CL, Polansky MM, Anderson RA (2000) Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. Journal of Agricultural and Food Chemistry 48:849-852.
5. Bruneton R.L.Antimicrobial (1999) antioxidant and cytotoxic activities and phytochemical screening o some yemeni medicinal plants. Evidence Complementary and Alternative Medecine 7:323-330.
6. Cao H, Polansky M, Anderson RA (2007) Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes. Archives of Biochemistry and Biophysics 459:214-222.
7. Crawley JN (1999) Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Research 835:18-26.
8. David J, Alvin CP (2013) La polyneuropathie diabétique douloureuse. Médecine clinique endocrinologie et diabète 56:21-28.
9. Daisy P, Feril G, Kani J (2012) Evaluation of antidiabetic activity of various extracts of cassia auriculata linn. Bark on streptozotocin induced diabetic wistar rats. International Journal of Pharmacy and Pharmaceutical Sciences 4:312-318.
10. Delpech R (2015) état des lieux passé et actuel de l’insuline (thérapies et procédés) et perspectives d’évolution. Thèse de doctorat, pharmacie, université Toulouse paul sabatier, France.
11. Duke J (1992) Handbook of Phytomedical Constituents of GRAS Herbs and Other Economic Plants. Boca Raton, FL Press, Inc.
12. Elizalde N, Gil-Bea FJ, Ramirez MJ, Aisa B, Lasheras B, Del Rio J, Tordea RM (2008) Long-lasting behavioral effects and recognition memory deficit induced by chronic mild stress in mice: effect of antidepressant treatment. Psychopharmacology199:1-14.
13. Etuk E, Muhammed B (2010) Evidence Based Analysis of Chemical Method of Induction of Diabetes Mellitus in Experimental Animals. International Journal of Research in Pharmaceutical Sciences 1:2.
14. Ghika (2003) Intervention and cardiovascular disease in patients with type 2 diabetes 348:383-93.
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16. Hall CS (1934) Emotional behavior in the rat. Journal of Comparative Physical 18:385-403
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21. Kim W, Khil L Y, Clark R, Bok S. H, Kim E. E, Lee S, Jun H. S , Yoon J. W (2006) Naphthalenemethyl ester derivative of dihydroxyhydrocinnamic acid, a component of cinnamon, increases glucose disposal by enhancing translocation of glucose transporter 4. Diabetologia 49: 2437-2448.
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26. Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y (2004) Cinnamon extract prevents the insulin resistance induced by a high-fructose diet. Horm Metab Res 36:119-125.
27. Roussel.A.M (2013) Prise en charge du stress et de l’anxiété: Quelle place pour les composés bio-actifs naturels? la lettre de l’Institut Européen de Physionutrition et de Phytothérapie 28:4-6.
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29. Sanez A, Villagro OR (2006) Trias JF.Factor analysis of forced swimming test, Sucrose Perferance test and Open Field test on enriched, social and isolated reared rats. Behavior Brain Research 169:57-65.
30. Sarakhail P, Rahmanipour S, Fadyevatan S, Mohammadirad A, Dehghan G, Amin G, Shafiee A, Abdollahi M (2007) Antidiabetic effect of Phlomis anisodonta: Effects on hepatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Pharmacological Research 56:261-266.
31. Scalbert A, Manach C, Morand C, Remesy C, Jimenez, L (2005) Dietary polyphenols and the prevention of diseases. Critical Reviews in Food Science and Nutrition 45:287-306.
32. Shan B, Cai Y.Z, Sun M, Corke, H (2005) Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. Journal of Agricultural and Food Chemistry 53:7749-7759.
33. Subash BP, Prabuseenivasan S, Ignacimuthu S (2007) Cinnamaldehyde - a potential antidiabetic agent. Phytomedicine 14:15-22.
34. Surwit L (2002) Neuropathic pain. Redefinition and a grading system for clinical and research purposes. Neurology 70:1630-1635
35. Thiebaut S, Guillaume S, Courtet P (2010) dépression et diabète. CHU Montpellier & Université de Montpellier, France, pp 02-04.
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37. Wens J, Sunaert P, Nobels F, Feyen L, Crombruggen P.C, Bastiaens H, Royen PV (2007) Diabète Sucré de type 2 Société Scientifique de Médecine Générale SSMG; pp. 7-71.
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to cite

Boudiaf, F., Chouba, I., Amri, N., & Tahraoui, A. (2020). Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats. Journal of Animal Behaviour and Biometeorology, 8(3), 190–195. Retrieved from https://malque.pub/ojs/index.php/jabb/article/view/841

[1] Adisakwattana S, Roengsamran S, Hsu WH, Yibchok-anun S (2005) Mechanisms of antihyperglycemic effect of p-methoxycinnamic acid in normal and streptozotocin-induced diabetic rats. Life Sci 78:406-412.

[2] Aggarwal BB, Sung B (2009) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern tragets trend pharmacol. Science 30:85-94

[3] Anderson P, Phillips K, Stoecklin G, Kedersha N (2004) Post-transcriptional regulation of proinflammatory proteins. Journal of Leukocyte Biology 76:42-47.

[4] Broadhurst CL, Polansky MM, Anderson RA (2000) Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. Journal of Agricultural and Food Chemistry 48:849-852.

[5] Bruneton R.L.Antimicrobial (1999) antioxidant and cytotoxic activities and phytochemical screening o some yemeni medicinal plants. Evidence Complementary and Alternative Medecine 7:323-330.

[6] Cao H, Polansky M, Anderson RA (2007) Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes. Archives of Biochemistry and Biophysics 459:214-222.

[7] Crawley JN (1999) Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Research 835:18-26.

[8] David J, Alvin CP (2013) La polyneuropathie diabétique douloureuse. Médecine clinique endocrinologie et diabète 56:21-28.

[9] Daisy P, Feril G, Kani J (2012) Evaluation of antidiabetic activity of various extracts of cassia auriculata linn. Bark on streptozotocin induced diabetic wistar rats. International Journal of Pharmacy and Pharmaceutical Sciences 4:312-318.

[10] Delpech R (2015) état des lieux passé et actuel de l’insuline (thérapies et procédés) et perspectives d’évolution. Thèse de doctorat, pharmacie, université Toulouse paul sabatier, France.

[11] Duke J (1992) Handbook of Phytomedical Constituents of GRAS Herbs and Other Economic Plants. Boca Raton, FL Press, Inc.

[12] Elizalde N, Gil-Bea FJ, Ramirez MJ, Aisa B, Lasheras B, Del Rio J, Tordea RM (2008) Long-lasting behavioral effects and recognition memory deficit induced by chronic mild stress in mice: effect of antidepressant treatment. Psychopharmacology199:1-14.

[13] Etuk E, Muhammed B (2010) Evidence Based Analysis of Chemical Method of Induction of Diabetes Mellitus in Experimental Animals. International Journal of Research in Pharmaceutical Sciences 1:2.

[14] Ghika (2003) Intervention and cardiovascular disease in patients with type 2 diabetes 348:383-93.

[15] Grimaldi A (2000) Diabétologie, Questions d’internat, université Pierre et Marie Curie, Faculté de médecine pp15 ,19, 29:142.

[16] Hall CS (1934) Emotional behavior in the rat. Journal of Comparative Physical 18:385-403

[17] Hernández I, Alegre L, Van Breusegem F, Munné-Bosch S (2009) Trends in Plant Science 14:125-132.

[18] Hiramatsu Y, Sekiguchi N, Hayashi M, Isshiki K, Yokota T, King GL, Loeken MR (2002) Diacylglycerol production and protein Kinase C activity are increased in a mouse model of diabetic embryopathy diabetes 51:2804-2810.

[19] Karl T, Pabst R, Von Horsten S (2003) Behavioral phenotyping of mice in pharmacological and toxicological research. Experimental Toxicology Pathology 55:69-83

[20] Khan A, Bryden NA, Polansky MM, Anderson RA (1990) Insulin potentiating factor and chromium content of selected foods and spices. Biological Trace Elements Research 24:183-188.

[21] Kim W, Khil L Y, Clark R, Bok S. H, Kim E. E, Lee S, Jun H. S , Yoon J. W (2006) Naphthalenemethyl ester derivative of dihydroxyhydrocinnamic acid, a component of cinnamon, increases glucose disposal by enhancing translocation of glucose transporter 4. Diabetologia 49: 2437-2448.

[22] Marles R.J, Norman R.F (1994) Plants as source of antidiabetic agents. In, Economic and medicinal plants research, London, H, Wagner and N.R., Farwoth, 112-09

[23] Martin J, Wang ZQ, Zhang XH, Wachtel D, Volaufova J, Matthews DE, Cefalu WT (2006) Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 29:1826-1832.

[24] Prasad NS, Raghavendra R, Lokesh BR, Naidu KA (2004) Spice phenolics inhibit human PMNL 5-lipoxygenase. Prostaglandins Leukot Essent Fatty Acids 70:521-528.

[25] Prut L, Belzung C (2003) The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. European Journal of Pharmacology 463:3

[26] Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y (2004) Cinnamon extract prevents the insulin resistance induced by a high-fructose diet. Horm Metab Res 36:119-125.

[27] Roussel.A.M (2013) Prise en charge du stress et de l’anxiété: Quelle place pour les composés bio-actifs naturels? la lettre de l’Institut Européen de Physionutrition et de Phytothérapie 28:4-6.

[28] Saffidine K (2015) Etude analytique et biologique des flavonoïdes extraits de Carthamus caeruleus L. et de Plantago major L, thèse de doctorat, microbiologie,université Farhat Abes Sétif, Algérie, pp 4,15.

[29] Sanez A, Villagro OR (2006) Trias JF.Factor analysis of forced swimming test, Sucrose Perferance test and Open Field test on enriched, social and isolated reared rats. Behavior Brain Research 169:57-65.

[30] Sarakhail P, Rahmanipour S, Fadyevatan S, Mohammadirad A, Dehghan G, Amin G, Shafiee A, Abdollahi M (2007) Antidiabetic effect of Phlomis anisodonta: Effects on hepatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Pharmacological Research 56:261-266.

[31] Scalbert A, Manach C, Morand C, Remesy C, Jimenez, L (2005) Dietary polyphenols and the prevention of diseases. Critical Reviews in Food Science and Nutrition 45:287-306.

[32] Shan B, Cai Y.Z, Sun M, Corke, H (2005) Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. Journal of Agricultural and Food Chemistry 53:7749-7759.

[33] Subash BP, Prabuseenivasan S, Ignacimuthu S (2007) Cinnamaldehyde - a potential antidiabetic agent. Phytomedicine 14:15-22.

[34] Surwit L (2002) Neuropathic pain. Redefinition and a grading system for clinical and research purposes. Neurology 70:1630-1635

[35] Thiebaut S, Guillaume S, Courtet P (2010) dépression et diabète. CHU Montpellier & Université de Montpellier, France, pp 02-04.

[36] Urquiaga I, Leighton F (2000) Plant polyphenol antioxidant and oxidative stress. Biological Research 33:55-6411.

[37] Wens J, Sunaert P, Nobels F, Feyen L, Crombruggen P.C, Bastiaens H, Royen PV (2007) Diabète Sucré de type 2 Société Scientifique de Médecine Générale SSMG; pp. 7-71.

[38] Witters LA (2001) The blooming of the French lilac. The journal of clinical investigation 108:1105-1107.

Abstract

References

How to cite