In the face of climate change, the eco-dromedary seems to adapt to meteorological constraints. This work compares the skin of the forehead, the hump, and the axillary part of two populations of Algerian dromedaries, namely the Sahraoui and Targui. We worked on six young adult dromedaries of two populations and two sexes genders. We removed the skin from the forehead, the hump, and the axillary part; they were fixed in 10% of formalin. After 48 hours of fixation, the different samples were subjected to different stages of histological techniques. Sections were stained with hematoxylin-eosin. After mounting the slides, we proceeded to microscopic observations and calculations of each layer of skin thickness. The different skin layers were similar in all body regions dromedaries for the two populations. By comparing the thickness of the skin layers of two sexes and two populations, we notice that the skin from the axillary part of male Sahraoui dromedary is the thickest with the measures 0.0413±0.0222 cm, 0.9789±0.1397 cm, and 2.8119±0.1266 cm for epidermis, dermis, and hypodermis, respectively. The thinnest skin was found in the forehead of the male Targui dromedary with 0.0494±0.0095 cm, 0.2191±0.0536 cm, and 0.3302±0.0835 cm for epidermis, dermis, and hypodermis, respectively. The thickness variation of the skin parts of dromedary between sexes in the same population and between the populations suggests an implication of the adaptation system of dromedary to climatic conditions.