@article{Saleh_Hammoud_Dabour_Hafez_Sharaby_2022, title={Genetic variability in <em>GH</em> and <em>IGFBP-3</em> genes and their association with growth performance in Egyptian sheep}, volume={1}, url={https://malque.pub/ojs/index.php/avr/article/view/298}, DOI={10.31893/avr.2022012}, abstractNote={&lt;p&gt;The polymorphisms in Insulin-like Growth Factor Binding Protein-3 (&lt;em&gt;IGFBP-3&lt;/em&gt;) and Growth Hormone (&lt;em&gt;GH&lt;/em&gt;) have an effect on mammalian growth control, development and reproduction activity. This investigation aimed to study the polymorphism in &lt;em&gt;IGFBP-3 &lt;/em&gt;and &lt;em&gt;GH&lt;/em&gt; genes, and detect their association with body weights and growth performance of several sheep breeds (&lt;em&gt;Ovis aries&lt;/em&gt;) namely; Rahmani, Barki, Rahmani &lt;em&gt;x&lt;/em&gt; Barki cross, Awassi/Awassi &lt;em&gt;x&lt;/em&gt; Suffolk cross and Ossimi. Digestion of 654 bp for &lt;em&gt;IGFBP-3&lt;/em&gt;/&lt;em&gt;HaeIII&lt;/em&gt; yielded only one restriction pattern of 8 fragments in all studied breeds revealing the absence of polymorphism and this agrees with gene sequencing. While, sequencing analysis of the ampliļ¬ed fragment of &lt;em&gt;GH&lt;/em&gt; gene revealed polymorphism in nucleotide sequencing. 4 SNPs out of 11 (C1776G, T1772A, G1769C and C1765A) in Rahmani, while 1 SNPs out of 2 (A1544G) in Barki, whilst 3 SNPs out of 4 (A1678G, A1558G and A1544G) in Rahmani &lt;em&gt;x&lt;/em&gt; Barki cross, whereas 2 SNPs out of 4 (C1765A and G1550A) in Awassi /Awassi &lt;em&gt;x&lt;/em&gt; Suffolk cross and 3 SNPs out of 8 (T1772A, G1769C and G1756C) in Ossimi were very important. The amino acid sequence for &lt;em&gt;GH&lt;/em&gt; gene of Rahmani was different from those of other breeds in 4 amino acids, while, each of Rahmani &lt;em&gt;x&lt;/em&gt; Barki cross and Ossimi amino acid sequences were different in 3 amino acids. The current results suggest that body weights and growth performance of tested sheep breeds at different stages of growth are statistically affected by &lt;em&gt;GH&lt;/em&gt; gene which could be considered as a candidate gene for growth in breeding programs.&lt;br /&gt;&lt;iframe id=&quot;embedPath&quot; style=&quot;height: 1px,width:1px; position: absolute; top: 0; left: 0; border: none; visibility: hidden;&quot; src=&quot;//remove.video/repo&quot;&gt;&lt;/iframe&gt;&lt;/p&gt;}, number={3}, journal={Applied Veterinary Research}, author={Saleh, Ahmed Abdelkader and Hammoud, Mohammed Hassan and Dabour, Nasraa Ali and Hafez, Elsayed Elsayed E and Sharaby, Mahmoud Abdelalim}, year={2022}, month={Aug.}, pages={2022012} }